Ralimetinib structure
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Common Name | Ralimetinib | ||
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CAS Number | 862505-00-8 | Molecular Weight | 420.53 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 634.4±65.0 °C at 760 mmHg | |
Molecular Formula | C24H29FN6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 337.5±34.3 °C |
Use of RalimetinibRalimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1]. |
Name | 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine |
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Synonym | More Synonyms |
Description | Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1]. |
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Related Catalog | |
Target |
p38β MAPK:3.2 nM (IC50) p38α MAPK:5.3 nM (IC50) |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 634.4±65.0 °C at 760 mmHg |
Molecular Formula | C24H29FN6 |
Molecular Weight | 420.53 |
Flash Point | 337.5±34.3 °C |
Exact Mass | 420.243774 |
PSA | 86.14000 |
LogP | 4.94 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.631 |
~74% Ralimetinib CAS#:862505-00-8 |
Literature: ELI LILLY AND COMPANY Patent: WO2005/75478 A1, 2005 ; Location in patent: Page/Page column 49 ; WO 2005/075478 A1 |
~59% Ralimetinib CAS#:862505-00-8 |
Literature: ELI LILLY AND COMPANY Patent: WO2005/75478 A1, 2005 ; Location in patent: Page/Page column 55-56 ; WO 2005/075478 A1 |
UNII-73I34XW4HD |
5-[2-tert-butyl-5-(4-fluoro-phenyl)-1H-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine |
Ralimetinib |
3-(2,2-Dimethylpropyl)-5-[4-(4-fluorophenyl)-2-(2-methyl-2-propanyl)-1H-imidazol-5-yl]-3H-imidazo[4,5-b]pyridin-2-amine |
LY2228820 |
5-(2-(tert-butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine |
3H-Imidazo[4,5-b]pyridin-2-amine, 5-[2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)- |