Zoniporide hydrochloride hydrate
Modify Date: 2024-01-12 06:51:55
Zoniporide hydrochloride hydrate structure
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Common Name | Zoniporide hydrochloride hydrate | ||
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| CAS Number | 863406-85-3 | Molecular Weight | 374.82500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19ClN6O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Zoniporide hydrochloride hydrateZoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2]. |
| Name | 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide,hydrate,hydrochloride |
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| Synonym | More Synonyms |
| Description | Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2]. |
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| Related Catalog | |
| Target |
IC50: 14 nM (NHE-1)[1] |
| In Vivo | Zoniporide hydrochloride hydrate (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED50=0.45 mg/kg/h) in open chest anesthetized rabbits[1]. Zoniporide exhibits moderate plasma protein binding, has a t1/2 of 1.5 hours in monkeys, and has one major active metabolite[1]. Zoniporide hydrochloride hydrate treatment shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively[2]. Animal Model: Rabbit[1] Dosage: 0.25, 1, 4 mg/kg Administration: Every hour for 2 hours; intravenous injection Result: Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED50 was 0.45 mg/kg/h. Animal Model: Rat[2] Dosage: 1 mg/kg Administration: Intravenous injection(Pharmacokinetic Analysis) Result: The AUC0-∞ and t1/2 were 0.07 μg h/mL and 0.5 hours, respectively. |
| References |
| Molecular Formula | C17H19ClN6O2 |
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| Molecular Weight | 374.82500 |
| Exact Mass | 374.12600 |
| PSA | 122.40000 |
| LogP | 4.03370 |
| Hazard Codes | Xi |
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| Zoniporide hydrochloride monohydrate |
| Zoniporide monohydrochloride monohydrate |