Casein Kinase II Inhibitor IV

Modify Date: 2024-01-13 17:50:04

Casein Kinase II Inhibitor IV Structure
Casein Kinase II Inhibitor IV structure
Common Name Casein Kinase II Inhibitor IV
CAS Number 863598-09-8 Molecular Weight 429.47100
Density N/A Boiling Point N/A
Molecular Formula C24H23N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Casein Kinase II Inhibitor IV


Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.

 Names

Name 3-[3-[2-(3,4,5-trimethoxyanilino)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]propanenitrile
Synonym More Synonyms

 Casein Kinase II Inhibitor IV Biological Activity

Description Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
Related Catalog
Target

Target: Casein Kinase[1]

In Vitro Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes[1].
Kinase Assay For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150 mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the NHEKs. After 24 h, the transfected cells are plated into 96-well assay plates and treated with compound (Casein Kinase II Inhibitor IV) to a final concentration of 5 μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system[1].
References

[1]. Hong J, et al. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chem Biol. 2007 Mar 20;2(3):171-5.

 Chemical & Physical Properties

Molecular Formula C24H23N5O3
Molecular Weight 429.47100
Exact Mass 429.18000
PSA 94.22000
LogP 4.71908
Storage condition 2-8℃

 Synonyms

Keratinocyte Differentiation Inducer
3-{3-[2-(3,4,5-trimethoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-propionitrile
HMS3229D03
Casein Kinase II Inhibitor IV
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