3-O-Ethyl-L-ascorbic acid

Modify Date: 2025-08-19 20:24:23

3-O-Ethyl-L-ascorbic acid Structure
3-O-Ethyl-L-ascorbic acid structure
 Common Name 3-O-Ethyl-L-ascorbic acid
CAS Number 86404-04-8 Molecular Weight 204.177
Density 1.5±0.1 g/cm3 Boiling Point 551.5±50.0 °C at 760 mmHg
Molecular Formula C8H12O6 Melting Point 112.0 to 116.0 °C
MSDS USA Flash Point 228.5±23.6 °C

 Use of 3-O-Ethyl-L-ascorbic acid


3-O-Ethyl-L-ascorbic acid, a stable vitamin C derivative, is a cosmetic tyrosinase tnhibitor with a whitening capacity. 3-O-Ethyl-L-ascorbic acid also has antioxidant abilities[1][2].

 Names

Name 3-O-Ethyl Ascorbic Acid
Synonym More Synonyms

 3-O-Ethyl-L-ascorbic acid Biological Activity

Description 3-O-Ethyl-L-ascorbic acid, a stable vitamin C derivative, is a cosmetic tyrosinase tnhibitor with a whitening capacity. 3-O-Ethyl-L-ascorbic acid also has antioxidant abilities[1][2].
Related Catalog
References

[1]. Wayne C Liao, et al. Antioxidant Ability and Stability Studies of 3- O-Ethyl Ascorbic Acid, a Cosmetic Tyrosinase Inhibitor. J Cosmet Sci. Jul/Aug 2018;69(4):233-243.

[2]. Fotis Iliopoulos, et al. 3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin. Int J Pharm X. 2019 Jul 19;1:100025.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 551.5±50.0 °C at 760 mmHg
Melting Point 112.0 to 116.0 °C
Molecular Formula C8H12O6
Molecular Weight 204.177
Flash Point 228.5±23.6 °C
Exact Mass 204.063385
PSA 96.22000
LogP -1.80
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.555
Storage condition 0-10°C

 Safety Information

Hazard Codes Xi
HS Code 2932209090

 Synthetic Route

5,6-O-isopropylidene-3-O-ethyl-L-ascorbic acid structure

5,6-O-isopropyl...

CAS#:86404-03-7

~10%

3-O-Ethyl-L-ascorbic acid Structure

3-O-Ethyl-L-asc...

CAS#:86404-04-8

Literature: Nihro, Yasunori; Sogawa, Satoshi; Izumi, Akihiro; Sasamori, Akihiro; Sudo, Tadamitsu; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1618 - 1623
Bromoethane structure

Bromoethane

CAS#:74-96-4

Ascorbic acid structure

Ascorbic acid

CAS#:50-81-7

~69%

3-O-Ethyl-L-ascorbic acid Structure

3-O-Ethyl-L-asc...

CAS#:86404-04-8

Literature: BIOGENICS, INC. Patent: WO2009/14343 A2, 2009 ; Location in patent: Page/Page column 21; 23 ;
Ethyl Mesilate structure

Ethyl Mesilate

CAS#:62-50-0

Ascorbic acid structure

Ascorbic acid

CAS#:50-81-7

~66%

3-O-Ethyl-L-ascorbic acid Structure

3-O-Ethyl-L-asc...

CAS#:86404-04-8

Literature: Kikugawa, Yasuo; Sakamoto, Takeshi; Sato, Shinya; Asami, Kayoko Heterocycles, 2005 , vol. 66, # 1 p. 579 - 582
Diethyl sulfate structure

Diethyl sulfate

CAS#:64-67-5

Ascorbic acid structure

Ascorbic acid

CAS#:50-81-7

~64%

3-O-Ethyl-L-ascorbic acid Structure

3-O-Ethyl-L-asc...

CAS#:86404-04-8

Literature: Kikugawa, Yasuo; Sakamoto, Takeshi; Sato, Shinya; Asami, Kayoko Heterocycles, 2005 , vol. 66, # 1 p. 579 - 582
5,6-0,0-isopropylidene-L-ascorbic acid structure

5,6-0,0-isoprop...

CAS#:15042-01-0

~%

3-O-Ethyl-L-ascorbic acid Structure

3-O-Ethyl-L-asc...

CAS#:86404-04-8

Literature: Journal of Medicinal Chemistry, , vol. 35, # 9 p. 1618 - 1623

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-O-Ethyl Ascorbyl Ether
Vc Ethyl Ether
(5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one (non-preferred name)
(5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-ethoxy-3-hydroxy-2(5H)-furanone
Vitamin C Ethyl Ether
3-O-Ethyl-L-ascorbic Acid
(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-ethoxy-4-hydroxy-2H-furan-5-one
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