Setipiprant structure
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Common Name | Setipiprant | ||
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CAS Number | 866460-33-5 | Molecular Weight | 402.418 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 690.4±55.0 °C at 760 mmHg | |
Molecular Formula | C24H19FN2O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 371.4±31.5 °C |
Use of SetipiprantSetipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma. |
Name | 2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid |
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Synonym | More Synonyms |
Description | Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma. |
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Related Catalog |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 690.4±55.0 °C at 760 mmHg |
Molecular Formula | C24H19FN2O3 |
Molecular Weight | 402.418 |
Flash Point | 371.4±31.5 °C |
Exact Mass | 402.137970 |
PSA | 62.54000 |
LogP | 3.39 |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.682 |
Storage condition | -20℃ |
[8-Fluoro-2-(1-naphthoyl)-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl]acetic acid |
Setipiprant |
5H-Pyrido[4,3-b]indole-5-acetic acid, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)- |
UNII-BHF20LA2GM |
2-(2-(1-Naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid |
ACT-129968 |