T-26c

Modify Date: 2024-01-09 16:41:38

T-26c Structure
T-26c structure
Common Name T-26c
CAS Number 869296-13-9 Molecular Weight 479.51
Density N/A Boiling Point N/A
Molecular Formula C24H21N3O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of T-26c


T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].

 Names

Name T-26c
Synonym More Synonyms

 T-26c Biological Activity

Description T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
Related Catalog
Target

IC50: 6.75 pM (MMP-13)[1]

In Vitro T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1].
References

[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.

 Chemical & Physical Properties

Molecular Formula C24H21N3O6S
Molecular Weight 479.51

 Synonyms

CPD1612
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