Maraniol
Maraniol structure
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Common Name | Maraniol | ||
|---|---|---|---|---|
| CAS Number | 87-05-8 | Molecular Weight | 204.222 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 351.4±37.0 °C at 760 mmHg | |
| Molecular Formula | C12H12O3 | Melting Point | 114-116 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 146.2±21.1 °C | |
Use of Maraniol7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2]. |
| Name | 7-Ethoxy-4-methylcoumarin |
|---|---|
| Synonym | More Synonyms |
| Description | 7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2]. |
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| Related Catalog | |
| Target |
CYP1A1 CYP2B6 CYP2B4 |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 351.4±37.0 °C at 760 mmHg |
| Melting Point | 114-116 °C(lit.) |
| Molecular Formula | C12H12O3 |
| Molecular Weight | 204.222 |
| Flash Point | 146.2±21.1 °C |
| Exact Mass | 204.078644 |
| PSA | 39.44000 |
| LogP | 2.90 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.548 |
| InChIKey | NKRISXMDKXBVRJ-UHFFFAOYSA-N |
| SMILES | CCOc1ccc2c(C)cc(=O)oc2c1 |
| Water Solubility | DMF: soluble |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
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~92%
Maraniol CAS#:87-05-8 |
| Literature: Synthetic Communications, , vol. 40, # 22 p. 3358 - 3364 |
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~38%
Maraniol CAS#:87-05-8 |
| Literature: European Journal of Medicinal Chemistry, , vol. 77, p. 400 - 408 |
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~98%
Maraniol CAS#:87-05-8 |
| Literature: Molecules, , vol. 10, # 3 p. 720 - 724 |
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~%
Maraniol CAS#:87-05-8 |
| Literature: Asian Journal of Chemistry, , vol. 25, # 12 p. 6609 - 6611 |
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~50%
Maraniol CAS#:87-05-8 |
| Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 6 p. 726 - 727 |
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~%
Maraniol CAS#:87-05-8 |
| Literature: US1934361 , ; |
CAS#:24535-08-8| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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CYP2A6: genetics, structure, regulation, and function.
Drug Metabol. Drug Interact. 27 , 73-88, (2012) The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and CYP2A13. The CYP2A6 gene is highly polymorphic with approximately 40 annotated allelic variants. Individuals homozygous fo... |
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Approach to detect substrates suitable to measure the coumarin 7-hydroxylase (Cyp 2a-5)-structure-activity relationships.
Arch. Pharm. (Weinheim) 327 , 299-302, (1994) Besides coumarin, which up to now has remained the most selective substrate for the coumarin 7-hydroxylase (Coh), 7-ethoxycoumarin, quinoline, 4-methylcoumarin, 7-ethoxy-4-methylcoumarin, 7-ethoxy-4-e... |
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7-Aminocoumarins are substrates of cytochrome P450-isozymes.
Arch. Pharm. (Weinheim) 331 , 143-148, (1998) N-Alkyl-7-aminocoumarins are dealkylated by murine cytochrome P450. There are differences between the N-dealkylation of secondary and tertiary amines. 7-Ethylamino-4-methylcoumarin is deethylated by i... |
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Name: Intrinsic clearance in human liver microsomes at 1 uM measured upto 120 mins in prese...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4627577
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Name: Half life in human liver microsomes at 1 uM measured up to 120 mins in presence of NA...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4627576
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Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
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Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2
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Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791
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Name: High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS1303
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Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
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Name: Antiasthamic activity in Wistar rat tracheal ring assessed as reversal of carbachol-i...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3269356
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Name: A screen for compounds that inhibit viral RNA polymerase binding and polymerization a...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Chain A, Poliovirus Polymerase With Gtp
External Id: HMS750
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| Maraniol |
| 7-ethoxy-4-methylchromen-2-one |
| 7-Ethoxy-4-methyl-2H-chromen-2-one |
| EINECS 201-721-5 |
| MFCD00016971 |