SCH-23390 maleate
Modify Date: 2026-07-03 11:23:59
SCH-23390 maleate structure
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Common Name | SCH-23390 maleate | ||
|---|---|---|---|---|
| CAS Number | 87134-87-0 | Molecular Weight | 324.24500 | |
| Density | N/A | Boiling Point | 414.7ºC at 760 mmHg | |
| Molecular Formula | C21H22ClNO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 204.6ºC | |
Use of SCH-23390 maleateSCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
D1 Receptor:0.2 nM (Ki) D5 Receptor:0.3 nM (Ki) 5-HT2C Receptor:9.3 nM (Ki) GIRK:268 nM (IC50) |
| In Vitro | SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4]. |
| In Vivo | SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1]. SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1]. SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 414.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C21H22ClNO5 |
| Molecular Weight | 324.24500 |
| Flash Point | 204.6ºC |
| Exact Mass | 323.08400 |
| PSA | 23.47000 |
| LogP | 4.40530 |
| InChIKey | FGHVSEXHEAUJBT-HFNHQGOYSA-N |
| SMILES | CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1.O=C(O)C=CC(=O)O |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striatal homo...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1936224
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Name: Antagonist activity at human D2 receptor expressed in CHO-K1 cells assessed as inhibi...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL4709829
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Name: Displacement of [3H]SCH-23390 from dopamine D1 like receptor in porcine striatal memb...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1815886
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Name: Selectivity ratio Ki for dopamine D2 like receptor in porcine striatal membranes to K...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1815888
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|
Name: Displacement of [3H]spiperone from dopamine D2 like receptor in porcine striatal memb...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1815887
|
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00069249 |
| unii-3t51j24n1f |
| SCH23390 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: Polar surface area (PSA) of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is 23.47000. |
| Q: What is the boiling point of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: Boiling point of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is 414.7ºC at 760 mmHg. |
| Q: What is the CAS number of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: CAS number of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is 87134-87-0. |
| Q: What is the LogP of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: LogP of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is 4.40530. |
| Q: What is the English name of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: The English name of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol. |
| Q: What is the molecular formula of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: Molecular formula of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is C21H22ClNO5. |
| Q: What is the SMILES notation of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: SMILES notation of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1.O=C(O)C=CC(=O)O. |
| Q: What English synonyms does (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol have? |
| A: English synonyms of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol: MFCD00069249, unii-3t51j24n1f, SCH23390. |
| Q: What is the InChIKey of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: InChIKey of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is FGHVSEXHEAUJBT-HFNHQGOYSA-N. |
| Q: What is the molecular weight of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol? |
| A: Molecular weight of (Z)-but-2-enedioic acid,(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is 324.24500. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |