(-)-Denudatin B

Modify Date: 2026-07-14 17:22:39

(-)-Denudatin B structure	Common Name	(-)-Denudatin B
	CAS Number	87402-88-8	Molecular Weight	356.41
	Density	1.2±0.1 g/cm3	Boiling Point	491.1±45.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	214.2±28.8 °C

Use of (-)-Denudatin B

(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action

Name	Denudatin B
Synonym	More Synonyms

Description	(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47. [2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

References

[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47.

[2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

Density	1.2±0.1 g/cm3
Boiling Point	491.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₅
Molecular Weight	356.41
Flash Point	214.2±28.8 °C
Exact Mass	356.162384
PSA	53.99000
LogP	2.87
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.565
InChIKey	VDYACOATPFOZIO-HBUDHLSFSA-N
SMILES	C=CCC1=CC2(OC)C(=CC1=O)OC(c1ccc(OC)c(OC)c1)C2C

Hazard Codes	Xi

Name: Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL5110746

Name: Percent inhibition of [3H]-PAF binding to platelet-activating factor (PAF) receptor f...
Source: ChEMBL
Target: Platelet-activating factor receptor
External Id: CHEMBL764600

Name: Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL5110747

Name: Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte...
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110748

Name: Percent inhibition of [3H]PAF binding to platelet-activating factor (PAF) receptor fr...
Source: ChEMBL
Target: Platelet-activating factor receptor
External Id: CHEMBL764598

Name: Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte...
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110749

Name: Cytotoxicity against C57BL/6 mouse CD4+ T-lymphocytes at 500 nM measured upto 48 hrs
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110754

Name: Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte...
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110750

Name: Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte...
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110751

Name: Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte...
Source: ChEMBL
Target: CD4+ve Th
External Id: CHEMBL5110752

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(2S,3R,3aR)-5-Allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one

Denudatin B

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China
Product Name: (-)-Denudatin B
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
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(-)-Denudatin B

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