玉兰脂素B

• 常用名: 玉兰脂素B
• 英文名: (-)-Denudatin B
• CAS号: 87402-88-8
• 分子量: 356.41
• 密度: 1.2±0.1 g/cm3
• 沸点: 491.1±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄O₅
• 熔点: N/A
• 闪点: 214.2±28.8 °C

玉兰脂素B用途

(-)-去核素B是一种抗血小板药物。(-)-Denudatin B通过电压门控和受体操作的Ca2+通道抑制Ca2+内流,从而放松血管平滑肌[1]。(-)-去核素B具有非特异性抗血小板作用

玉兰脂素B名称

• 中文名: (-)-白玉兰亭 B
• 英文名: Denudatin B
• 中文别名: 玉兰脂素B

玉兰脂素B生物活性

• 描述: (-)-去核素B是一种抗血小板药物。(-)-Denudatin B通过电压门控和受体操作的Ca2+通道抑制Ca2+内流,从而放松血管平滑肌[1]。(-)-去核素B具有非特异性抗血小板作用
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47.

  [2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

玉兰脂素B物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 491.1±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄O₅
• 分子量: 356.41
• 闪点: 214.2±28.8 °C
• 精确质量: 356.162384
• PSA: 53.99000
• LogP: 2.87
• InChIKey: VDYACOATPFOZIO-HBUDHLSFSA-N
• SMILES: C=CCC1=CC2(OC)C(=CC1=O)OC(c1ccc(OC)c(OC)c1)C2C
• 外观性状: 油状物体
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.565
• 储存条件: 2-8℃，干燥，密闭

玉兰脂素B安全信息

• 危害码 (欧洲): Xi

玉兰脂素B靶点实验

查看更多实验

实验名称：Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5110746

实验名称：Percent inhibition of [3H]-PAF binding to platelet-activating factor (PAF) receptor f... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL764600

实验名称：Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5110747

实验名称：Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte... 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110748

实验名称：Percent inhibition of [3H]PAF binding to platelet-activating factor (PAF) receptor fr... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL764598

实验名称：Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte... 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110749

实验名称：Cytotoxicity against C57BL/6 mouse CD4+ T-lymphocytes at 500 nM measured upto 48 hrs 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110754

实验名称：Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte... 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110750

实验名称：Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte... 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110751

实验名称：Inhibition of cytokine storm in ConA/1L-12-stimulated C57BL/6 mouse CD4+ T-lymphocyte... 来源：ChEMBL 靶标：CD4+ve Th External Id：CHEMBL5110752

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玉兰脂素B英文别名

• (2S,3R,3aR)-5-Allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one
• Denudatin B