Thiocolchicoside structure
|
Common Name | Thiocolchicoside | ||
---|---|---|---|---|
CAS Number | 602-41-5 | Molecular Weight | 563.617 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 929.6±65.0 °C at 760 mmHg | |
Molecular Formula | C27H33NO10S | Melting Point | 190-198ºC | |
MSDS | Chinese USA | Flash Point | 516.0±34.3 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of ThiocolchicosideThiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. |
Name | Thiocolchicoside |
---|---|
Synonym | More Synonyms |
Description | Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. |
---|---|
Related Catalog | |
Target |
GABAA) receptor; glycine receptor[1] |
In Vitro | Thiocolchicoside (0.001, 0.1, 1, 10, 100 μM) reduces the amplitude of eIPSCs in a concentration-dependent manner with this effect being significant at 0.1 μM and maximal at 10 μM[1]. |
References |
Density | 1.5±0.1 g/cm3 |
---|---|
Boiling Point | 929.6±65.0 °C at 760 mmHg |
Melting Point | 190-198ºC |
Molecular Formula | C27H33NO10S |
Molecular Weight | 563.617 |
Flash Point | 516.0±34.3 °C |
Exact Mass | 563.182495 |
PSA | 189.31000 |
LogP | -1.23 |
Vapour Pressure | 0.0±0.3 mmHg at 25°C |
Index of Refraction | 1.657 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
---|---|
Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
RTECS | AC2976015 |
~96% Thiocolchicoside CAS#:602-41-5 |
Literature: Gelmi, Maria Luisa; Fontana, Gabriele; Pocar, Donato; Pontremoli, Guido; Pellegrino, Sara; Bombardelli, Ezio; Riva, Antonella; Balduini, Walter; Carloni, Silvia; Cimino, Mauro Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2245 - 2248 |
~% Thiocolchicoside CAS#:602-41-5 |
Literature: Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2245 - 2248 |
~% Thiocolchicoside CAS#:602-41-5 |
Literature: Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2245 - 2248 |
~% Thiocolchicoside CAS#:602-41-5 |
Literature: Bulletin de la Societe Chimique de France, , p. 198 |
~% Thiocolchicoside CAS#:602-41-5 |
Literature: Bulletin de la Societe Chimique de France, , p. 198 |
Thiocolchicoside |
Acetamide, N-[(7S)-3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]- |
UNII:T1X8S697GT |
Thiocolchicine Glycoside |
N-[(7S)-3-(b-D-glucopyranosyloxy)-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide |
R. 271 |
Coltramyl |
Musco-ril |
N-[(7S)-3-(β-D-Glucopyranosyloxy)-1,2-dimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide |
3,10-Di(demethoxy)-3-glucosyloxy-10-methylthiocolchicine |
10-Thiocolchicoside |
Tiocolchicoside |