WRW4 TFA

Modify Date: 2024-01-10 09:54:24

WRW4 TFA Structure
WRW4 TFA structure
Common Name WRW4 TFA
CAS Number 878557-55-2 Molecular Weight 1104.27000
Density N/A Boiling Point N/A
Molecular Formula C61H65N15O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WRW4 TFA


WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

 Names

Name L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl
Synonym More Synonyms

 WRW4 TFA Biological Activity

Description WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].
Related Catalog
In Vitro WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].
References

[1]. Bae YS, et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol. 2004;173(1):607-614.

 Chemical & Physical Properties

Molecular Formula C61H65N15O6
Molecular Weight 1104.27000
Exact Mass 1103.52000
PSA 355.46000
LogP 8.65230
Storage condition -20℃

 Synonyms

NPEC-caged-noradrenalin
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