15-Deoxy-Delta12

Modify Date: 2024-01-02 11:27:33

15-Deoxy-Delta12 structure	Common Name	15-Deoxy-Delta12
	CAS Number	87893-55-8	Molecular Weight	316.435
	Density	1.1±0.1 g/cm3	Boiling Point	495.8±34.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₃	Melting Point	N/A
	MSDS	USA	Flash Point	267.8±22.2 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of 15-Deoxy-Delta12

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

Name	15d-pgj2
Synonym	More Synonyms

Description	15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PPARγ:2 μM (EC50) PPARδ Human Endogenous Metabolite
In Vitro	15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].
References	[1]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278. [2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.

Density	1.1±0.1 g/cm3
Boiling Point	495.8±34.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	267.8±22.2 °C
Exact Mass	316.203857
PSA	54.37000
LogP	5.10
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.558

15-Deoxy-Delta12 MSDS(Chinese)

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes	F: Flammable;Xi: Irritant;
Risk Phrases	R11
Safety Phrases	16-26-29-33-36/37/39
RIDADR	UN 1231

Precursor 9
CAS#:869801-20-7 aldehyde compound CAS#:1253966-22-1 (Z)-methyl 7-((... CAS#:60410-16-4 (1S,4R)-4-Hydro... CAS#:660430-04-6 methyl [(1S,4S)...
CAS#:426226-00-8 dimethyl (1R,4S... CAS#:676235-98-6 [(1S,4S)-4-[(te... CAS#:676236-01-4 (4R,2'Z)-4-[7'-... CAS#:869801-10-5 (1S,4R,2'Z)-4-[...
CAS#:869801-19-4 alcohol compound
DownStream 0

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Lipidomics reveals a remarkable diversity of lipids in human plasma.

J. Lipid Res. 51(11) , 3299-305, (2010)

The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a ...

delta12,14-Pgj 2

15-Deoxy-D-12,14-prostaglandin J2

Prosta-5,9,12,14-tetraen-1-oic acid, 11-oxo-, (5Z,12E,14E)-

15-Deoxy-D12,14-PGJ2

PROSTAGLANDIN J2,15-DEOXY-DELTA12,14

11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC

15-DEOXY-DELTA12,14-PROSTAGLANGIN J2

15-DEOXY-DELTA12,14-PGJ2

MFCD00065806

15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2

(5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid

15-Deoxy-delta12,14-prostaglandin

(5Z,12E,14E)-11-Oxoprosta-5,9,12,14-tetraen-1-oic acid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 15-Deoxy-Δ12,14-prostaglandinJ2
Price: Negotiable
Purity: 97.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 15-Deoxy-Δ-12,14-prostaglandin J2
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: 15-Deoxy-Δ-12,14-prostaglandin J2
Price: $Inquiry/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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