Polygalasaponin F

Modify Date: 2024-01-04 17:17:59

Polygalasaponin F Structure
Polygalasaponin F structure
Common Name Polygalasaponin F
CAS Number 882664-74-6 Molecular Weight 1091.236
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C53H86O23 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Polygalasaponin F


Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway [1].

 Names

Name 3-O-β-D-galactopyranosylbayogenin 28-O-[β-D-xylopyranosyl-(1->4)-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranosyl] ester
Synonym More Synonyms

 Polygalasaponin F Biological Activity

Description Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway [1].
Related Catalog
Target

TLR4

PI3K

Akt

NF-κB

References

[1]. Yan WF , et al. The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res. 2015;17(6):662-70.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C53H86O23
Molecular Weight 1091.236
Exact Mass 1090.556030
PSA 374.13000
LogP 2.32
Index of Refraction 1.640

 Synonyms

β-D-Xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]-β-D-glucopyranose
Polygalasaponin F
POLYGALASAPONIN F (REFERENCE GRADE)
3-O--D-galactopyranosylbayogenin 28-O-[-D-xylopyranosyl-(1->4)--L-rhamnopyranosyl-(1->2)--D-glucopyranosyl] ester
Polygalasaponin-F
β-D-Glucopyranose, O-β-D-xylopyranosyl-(1->4)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]-
PolygalasaponinF
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