S14161

• 常用名: S14161
• 英文名: S14161
• CAS号: 883046-50-2
• 分子量: 315.30
• 密度: 1.3±0.1 g/cm3
• 沸点: 456.2±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄FNO₄
• 熔点: N/A
• 闪点: 229.7±28.7 °C

S14161用途

Pichromene (S14161) 是一种抗癌剂和弱 PI3K 抑制剂。Pichromene 能有效抑制白血病小鼠模型中的肿瘤生长,可用于癌症的研究。

S14161名称

• 英文名: 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene

S14161生物活性

• 描述: Pichromene (S14161) 是一种抗癌剂和弱 PI3K 抑制剂。Pichromene 能有效抑制白血病小鼠模型中的肿瘤生长,可用于癌症的研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 参考文献:

  [1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97.

  [2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73.

S14161物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 456.2±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄FNO₄
• 分子量: 315.30
• 闪点: 229.7±28.7 °C
• 精确质量: 315.090698
• PSA: 64.28000
• LogP: 4.60
• InChIKey: BFZXDHIUPNWOMT-UHFFFAOYSA-N
• SMILES: CCOc1cccc2c1OC(c1ccc(F)cc1)C([N+](=O)[O-])=C2
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.613
• 储存条件: -20°C，密闭，干燥

S14161靶点实验

查看更多实验

实验名称：Inhibition of PI3K in human HeLa cells assessed as inhibition of EGF1-induced AKT pho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2387937

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Antiangiogenic activity in HUVEC assessed as inhibition of cell migration by measurin... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL2387939

实验名称：Inhibition of PI3K in human SKOV3 cells assessed as inhibition of EGF1-induced AKT ph... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2387938

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Induction of apoptosis in human A549 cells assessed as activation of caspase-3 at 10 ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL2390648

实验名称：Growth inhibition of human PC3 cells at 20 uM after 72 hrs by SRB assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL2389508

实验名称：Growth inhibition of human SKOV3 cells at 20 uM after 72 hrs by SRB assay 来源：ChEMBL 靶标：SK-OV-3 External Id：CHEMBL2389507

实验名称：Growth inhibition of human H47D cells at 20 uM after 72 hrs by SRB assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2389506

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S14161英文别名

• 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene