Salmeterol

Modify Date: 2024-01-02 18:11:45

Salmeterol Structure
Salmeterol structure
 Common Name Salmeterol
CAS Number 89365-50-4 Molecular Weight 415.566
Density 1.1±0.1 g/cm3 Boiling Point 603.0±55.0 °C at 760 mmHg
Molecular Formula C25H37NO4 Melting Point N/A
MSDS N/A Flash Point 318.5±31.5 °C

 Use of Salmeterol


Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma.Target: beta2-Adrenergic ReceptorSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). salmeterol also binds with very high affinity at a second site, termed the "exosite", and that this exosite contributes to the long duration of action of salmeterol [1].

 Names

Name 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol
Synonym More Synonyms

 Salmeterol Biological Activity

Description Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma.Target: beta2-Adrenergic ReceptorSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). salmeterol also binds with very high affinity at a second site, termed the "exosite", and that this exosite contributes to the long duration of action of salmeterol [1].
Related Catalog
References

[1]. Rong, Y., et al., Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Biochemistry, 1999. 38(35): p. 11278-86.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 603.0±55.0 °C at 760 mmHg
Molecular Formula C25H37NO4
Molecular Weight 415.566
Flash Point 318.5±31.5 °C
Exact Mass 415.272247
PSA 81.95000
LogP 3.07
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.566
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ6457000
CHEMICAL NAME :
1,3-Benzenedimethanol, 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)met hyl)-, (+-)-
CAS REGISTRY NUMBER :
89365-50-4
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H37-N-O4
MOLECULAR WEIGHT :
415.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5600 ug/kg/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in spleen Immunological Including Allergic - decreased immune response
REFERENCE :
IJIMDS International Journal of Immunopharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979- Volume(issue)/page/year: 18,523,1996

 Safety Information

RTECS CZ6457000
HS Code 2922509090

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

(+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi
SAMETEROL
SalmeterolXenofoate
4-Hydroxy-3-[hydroxymethyl]phenyl-N-[6-phenylbutoxyhexyl]ethanolamine
Salmeterol
2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol
2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol
2-hydroxymethyl-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol
(±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol
MFCD00867037
serevent (R)
(±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-m-xylene-a,a1-diol
1,3-Benzenedimethanol, 4-hydroxy-α-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-
SALMETEROL(SUBJECTTOPATENTFREE)
4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL
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Chemsrc provides Salmeterol(CAS#:89365-50-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Salmeterol are included as well.>> amp version: Salmeterol

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