Lipoxin A4
Lipoxin A4 structure
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Common Name | Lipoxin A4 | ||
|---|---|---|---|---|
| CAS Number | 89663-86-5 | Molecular Weight | 352.47 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 589.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 324.3±26.6 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
Use of Lipoxin A4Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3]. |
| Name | lipoxin a4 |
|---|---|
| Synonym | More Synonyms |
| Description | Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3]. |
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| Related Catalog | |
| In Vitro | Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs[2]. Lipoxin A4 downregulates the expression of cyclin D1[2]. Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs[2]. LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL)[2]. LXA4 pretreatment (100 nM for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes[1]. Cell Proliferation Assay[2] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 100 nM Incubation Time: 30 minutes Result: A significant increase in proliferation of NHEKs after 7 days of stimulation with LPS (10 μg/mL) was seen. However, there was a significant decrease in the proliferation of NHEKs when pretreated with LXA4 for 30 min. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 100 nM Incubation Time: 30 minutes. Result: HMGB1 protein levels in the cytoplasm of NHEKs were induced by LPS, which were decreased after preincubation with LXA4 but decreased in the nucleus after stimulation with LPS. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 589.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H32O5 |
| Molecular Weight | 352.47 |
| Flash Point | 324.3±26.6 °C |
| Exact Mass | 352.224976 |
| PSA | 97.99000 |
| LogP | 2.43 |
| Vapour Pressure | 0.0±3.8 mmHg at 25°C |
| Index of Refraction | 1.541 |
| InChIKey | IXAQOQZEOGMIQS-SSQFXEBMSA-N |
| SMILES | CCCCCC(O)C=CC=CC=CC=CC(O)C(O)CCCC(=O)O |
| Symbol |
GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F: Flammable; |
| Risk Phrases | 11 |
| Safety Phrases | 7-16 |
| RIDADR | UN 1170 3/PG 2 |
| HS Code | 2918199090 |
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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HMDB: a knowledgebase for the human metabolome.
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m... |
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Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.
Br. J. Pharmacol. 172(3) , 910-23, (2015) Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was t... |
| LIPOXIN A |
| Lipoxin A4 |
| LXA |
| (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-Trihydroxy-7,9,11,13-icosatetraenoic acid |
| LXA4 |
| 5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid |