BMH 21

Modify Date: 2024-01-02 12:17:27

BMH 21 structure	Common Name	BMH 21
	CAS Number	896705-16-1	Molecular Weight	360.409
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀N₄O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of BMH 21

BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.IC50 value: 10-90 nM(RPA195 IC50) [1]Target: RNA Pol I inhibitorin vitro: BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress [1].

Name	N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Synonym	More Synonyms

Description	BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.IC50 value: 10-90 nM(RPA195 IC50) [1]Target: RNA Pol I inhibitorin vitro: BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress [1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
References	[1]. Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5(12):4361-9. [2]. Colis L, et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61. [3]. Peltonen K, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

Description

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Cancer

References

[1]. Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5(12):4361-9.

[2]. Colis L, et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61.

[3]. Peltonen K, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₁H₂₀N₄O₂
Molecular Weight	360.409
Exact Mass	360.158630
PSA	66.71000
LogP	1.57
Appearance of Characters	light yellow to dark yellow
Index of Refraction	1.668
Storage condition	2-8°C
Water Solubility	DMSO: soluble1mg/mL, clear (warmed)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport

1,1-Dimethyleth...

CAS#:108-00-9

12-Oxo-12H-benz...

CAS#:63127-04-8

~56%

BMH 21

CAS#:896705-16-1

Literature: Colis, Laureen; Ernst, Glen; Sanders, Sara; Liu, Hester; Sirajuddin, Paul; Peltonen, Karita; Depasquale, Michael; Barrow, James C.; Laiho, Marikki Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4950 - 4961

2-Chloronicotin...

CAS#:2942-59-8

BMH 21

CAS#:896705-16-1

3-Amino-2-napht...

CAS#:5959-52-4

BMH 21

CAS#:896705-16-1

Precursor 4
CAS#:108-00-9 1,1-Dimethyleth... CAS#:63127-04-8 12-Oxo-12H-benz... CAS#:2942-59-8 2-Chloronicotin... CAS#:5959-52-4 3-Amino-2-napht...
DownStream 0

N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

BMH-21

BMH21

DC Chemicals Limited
China
Product Name: BMH-21
Price: $400.0/100mg $750.0/250mg $1400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

BMH 21 suppliers

Price: $92/10mM*1mLinDMSO

Reference only. check more BMH 21 price

BMH 21

Use of BMH 21

Names

BMH 21 Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms