BMH-21

• 常用名: BMH-21
• 英文名: BMH 21
• CAS号: 896705-16-1
• 分子量: 360.409
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₁H₂₀N₄O₂
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

BMH-21用途

BMH-21是一新型DNA嵌入剂(DNA intercalator),能结合rDNA并抑制RNA polymerase I的转录,不使组蛋白H2AX磷酸化。

BMH-21名称

• 中文名: N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[g]吡啶并[2,1-b]喹唑啉-4-甲酰胺
• 英文名: N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

BMH-21生物活性

• 描述: BMH-21是一新型DNA嵌入剂(DNA intercalator),能结合rDNA并抑制RNA polymerase I的转录,不使组蛋白H2AX磷酸化。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 癌症
• 参考文献:

  [1]. Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5(12):4361-9.

  [2]. Colis L, et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61.

  [3]. Peltonen K, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

BMH-21物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₁H₂₀N₄O₂
• 分子量: 360.409
• 精确质量: 360.158630
• PSA: 66.71000
• LogP: 1.57
• InChIKey: BXYDVWIAGDJBEC-UHFFFAOYSA-N
• SMILES: CN(C)CCNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12
• 外观性状: light yellow to dark yellow
• 折射率: 1.668
• 储存条件: 2-8°C
• 水溶解性: DMSO: soluble1mg/mL, clear (warmed)

BMH-21安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

BMH-21靶点实验

查看更多实验

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：Inhibition of RNA polymerase 1 in human A-375 assessed as RPA194 degradation measured... 来源：ChEMBL 靶标：DNA-directed RNA polymerase I subunit RPA1 External Id：CHEMBL5038526

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：Inhibition of RPA2 in human A-375 cells assessed as downregulation of RPA2 gene at 1 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5038531

实验名称：Inhibition of RPA1 in human A-375 cells assessed as downregulation of RPA1 gene at 1 ... 来源：ChEMBL 靶标：DNA-directed RNA polymerase I subunit RPA1 External Id：CHEMBL5038530

实验名称：Drug screen in HD-MB03 medulloblastoma cells to determine synergistic drug combinatio... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HD-MB03

实验名称：Drug screen in CRL2098 osteosarcoma cells to determine synergistic drug combinations ... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_CRL2098

实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：Cytotoxicity against human HeLa cells 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4732607

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BMH-21英文别名

• N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
• BMH-21
• BMH21