ML348

Modify Date: 2024-01-07 21:59:43

ML348 Structure
ML348 structure
Common Name ML348
CAS Number 899713-86-1 Molecular Weight 415.794
Density 1.4±0.1 g/cm3 Boiling Point 546.2±50.0 °C at 760 mmHg
Molecular Formula C18H17ClF3N3O3 Melting Point N/A
MSDS N/A Flash Point 284.2±30.1 °C

 Use of ML348


ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.target: LYPLA1 [1]IC 50: 210 nM [1]

 Names

Name N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)-1-piperazinyl]acetamide
Synonym More Synonyms

 ML348 Biological Activity

Description ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.target: LYPLA1 [1]IC 50: 210 nM [1]
Related Catalog
References

[1]. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 546.2±50.0 °C at 760 mmHg
Molecular Formula C18H17ClF3N3O3
Molecular Weight 415.794
Flash Point 284.2±30.1 °C
Exact Mass 415.091064
LogP 3.28
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.570
Storage condition 2-8℃

 Synonyms

1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)-1-piperazinyl]acetamide
ML-348
ML348
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