Bromelain

Modify Date: 2024-01-01 22:22:23

Bromelain structure	Common Name	Bromelain
	CAS Number	9001-00-7	Molecular Weight	226.232
	Density	1.4±0.1 g/cm3	Boiling Point	656.2±55.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₄N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	350.7±31.5 °C

Use of Bromelain

Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2].

Name	Bromelain
Synonym	More Synonyms

Description	Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vivo	Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion[1]. Animal Model: Male Sprague-Dawley rats injected with 6-OHDA[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; daily; for 7 days Result: Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).
References	[1]. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22. [2]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.

Density	1.4±0.1 g/cm3
Boiling Point	656.2±55.0 °C at 760 mmHg
Molecular Formula	C₉H₁₄N₄O₃
Molecular Weight	226.232
Flash Point	350.7±31.5 °C
Exact Mass	226.106583
LogP	-2.17
Appearance of Characters	powder \| yellow-brown
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.591
Storage condition	−20°C
Water Solubility	soluble