FPA 124
Modify Date: 2024-01-08 08:41:48
FPA 124 structure
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Common Name | FPA 124 | ||
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| CAS Number | 902779-59-3 | Molecular Weight | 381.72500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H9Cl2CuN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FPA 124FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2]. |
| Name | FPA 124,Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamidecoppercomplex |
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| Synonym | More Synonyms |
| Description | FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2]. |
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| Related Catalog | |
| In Vitro | FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively[1]. |
| In Vivo | FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells[1]. |
| References |
| Molecular Formula | C11H9Cl2CuN3O2S |
|---|---|
| Molecular Weight | 381.72500 |
| Exact Mass | 379.90900 |
| PSA | 112.71000 |
| LogP | 3.42780 |
| fpa 124 |