Diprotin A

Modify Date: 2024-01-03 12:20:15

Diprotin A Structure
Diprotin A structure
Common Name Diprotin A
CAS Number 90614-48-5 Molecular Weight 341.44600
Density 1.14 g/cm3 Boiling Point 583.1ºC at 760 mmHg
Molecular Formula C17H31N3O4 Melting Point N/A
MSDS Chinese USA Flash Point 306.5ºC

 Use of Diprotin A


Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

 Names

Name diprotin a
Synonym More Synonyms

 Diprotin A Biological Activity

Description Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].
Related Catalog
Target

IC50: DPP-IV[1]

In Vitro Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1]. Western Blot Analysis[1] Cell Line: Human endothelial cells[1] Concentration: 100 μM Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
In Vivo Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice[1] Dosage: 70 μg/kg Administration: Intraperitoneal injection; twice daily; 7 days Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
References

[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

 Chemical & Physical Properties

Density 1.14 g/cm3
Boiling Point 583.1ºC at 760 mmHg
Molecular Formula C17H31N3O4
Molecular Weight 341.44600
Flash Point 306.5ºC
Exact Mass 341.23100
PSA 112.73000
LogP 1.99540
Index of Refraction 1.517
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR4737000
CHEMICAL NAME :
L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-
CAS REGISTRY NUMBER :
90614-48-5
LAST UPDATED :
199212
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H31-N3-O4
MOLECULAR WEIGHT :
341.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,422,1984

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NR4737000

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 Synonyms

MFCD00038707
H-ILE-PRO-ILE-OH
ILE-PRO-ILE H2O
Ile-Pro-Ile-OH
H-ILE-PRO-ILE-OH H2O
DIPEPTIDYLPEPTIDASE IV INHIBITOR I
L-Isoleucyl-L-prolyl-L-isoleucine
ILE-PRO-ILE
L-Ile-L-Pro-L-Ile-OH
Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: Diprotin A
  • Price: $250.0/100mg $500.0/250mg $1000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao



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