EC 144

Modify Date: 2024-01-10 01:05:48

EC 144 structure	Common Name	EC 144
	CAS Number	911397-80-3	Molecular Weight	413.90100
	Density	1.29±0.1 g/cm3(20 °C , 760mmHg)	Boiling Point	674.1±65.0 °C (760 mmHg)
	Molecular Formula	C₂₁H₂₄ClN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EC 144

EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1].

Name	4-Pentyn-2-ol, 5-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-
Synonym	More Synonyms

Description	EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Shi J, et al. EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem. 2012;55(17):7786-7795.

Density	1.29±0.1 g/cm3(20 °C , 760mmHg)
Boiling Point	674.1±65.0 °C (760 mmHg)
Molecular Formula	C₂₁H₂₄ClN₅O₂
Molecular Weight	413.90100
Exact Mass	413.16200
PSA	99.08000
LogP	3.82930

5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: EC 144
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: EC144
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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