Merafloxacin
Modify Date: 2024-01-05 13:19:26
Merafloxacin structure
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Common Name | Merafloxacin | ||
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| CAS Number | 91188-00-0 | Molecular Weight | 379.40100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23F2N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MerafloxacinMerafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. |
| Name | 1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
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| Synonym | More Synonyms |
| Description | Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. |
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| Related Catalog | |
| Target |
IC50: 19.6 μM (SARS-CoV-2)[1] |
| In Vitro | Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1]. |
| References |
| Molecular Formula | C19H23F2N3O3 |
|---|---|
| Molecular Weight | 379.40100 |
| Exact Mass | 379.17100 |
| PSA | 74.57000 |
| LogP | 2.88950 |
| 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Merafloxacin |
| 1-Ethyl-7-(3-ethylaminomethyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
| 1-ethyl-7-<3-<(ethylamino)methyl>-1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |