91188-00-0
91188-00-0 structure
- Name: Merafloxacin
- Chemical Name: 1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
- CAS Number: 91188-00-0
- Molecular Formula: C19H23F2N3O3
- Molecular Weight: 379.40100
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2018-04-19 18:21:38
- Modify Date: 2024-01-05 13:19:26
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Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].
| Name | 1-ethyl-7-[3-(ethylamino)methyl]-1-pyrrolidinyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
|---|---|
| Synonyms |
1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Merafloxacin 1-Ethyl-7-(3-ethylaminomethyl-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 1-ethyl-7-<3-<(ethylamino)methyl>-1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Description | Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 19.6 μM (SARS-CoV-2)[1] |
| In Vitro | Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1]. |
| References |
| Molecular Formula | C19H23F2N3O3 |
|---|---|
| Molecular Weight | 379.40100 |
| Exact Mass | 379.17100 |
| PSA | 74.57000 |
| LogP | 2.88950 |