Fosphenytoin (disodium)

Modify Date: 2024-01-02 19:01:33

Fosphenytoin (disodium) Structure
Fosphenytoin (disodium) structure
Common Name Fosphenytoin (disodium)
CAS Number 92134-98-0 Molecular Weight 406.23800
Density N/A Boiling Point N/A
Molecular Formula C16H13N2Na2O6P Melting Point 220ºC
MSDS N/A Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of Fosphenytoin (disodium)


Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.

 Names

Name disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
Synonym More Synonyms

 Fosphenytoin (disodium) Biological Activity

Description Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.
Related Catalog
In Vivo Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2].
Animal Admin A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination.
References

[1]. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80.

[2]. Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76.

 Chemical & Physical Properties

Melting Point 220ºC
Molecular Formula C16H13N2Na2O6P
Molecular Weight 406.23800
Exact Mass 406.03100
PSA 131.64000
LogP 2.69190
Storage condition 2-8°C
Water Solubility H2O: ≥15mg/mL

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase - N15.00950417
Hazard Codes T
Risk Phrases 45-61-22
Safety Phrases 53-36/37-45
RIDADR UN 2811 6.1 / PGIII
HS Code 2933790090

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Synonyms

Pro-Epanutin
ACC 9653-010
ACC 9653
Fosphenytoin disodium salt
CI 982
Cerebyx
Fosphenytoin sodium
Fosphenytoin (disodium)
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