Ajoene
Modify Date: 2024-01-08 19:56:31
Ajoene structure
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Common Name | Ajoene | ||
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| CAS Number | 92285-01-3 | Molecular Weight | 234.40200 | |
| Density | 1.181g/cm3 | Boiling Point | 376ºC at 760mmHg | |
| Molecular Formula | C9H14OS3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 181.2ºC | |
Use of AjoeneAjoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2]. |
| Name | Allyl[(2E)-3-(allyldisulfanyl)-2-propen-1-yl]sulfoniumolate |
|---|---|
| Synonym | More Synonyms |
| Description | Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2]. |
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| Related Catalog | |
| In Vitro | Ajoene shows cytotoxicity with IC50s in the 7-41 uM range for B16/BL6, HT-29, A549, MDA-MB231, PANC-1, and SKBR-3 cells[1]. |
| In Vivo | Ajoene (25 μg/g body weight of Ajoene in 100 mL Intralipid; i.p.; every other day from the day of inoculation up to day 28) inhibits both primary tumor growth[1]. Ajoene (25, 15 or 5 μg/g body weight of Ajoene in 100 μL Intralipid; i.p; every other day over 4 weeks) inhibits strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice[1]. |
| References |
| Density | 1.181g/cm3 |
|---|---|
| Boiling Point | 376ºC at 760mmHg |
| Molecular Formula | C9H14OS3 |
| Molecular Weight | 234.40200 |
| Flash Point | 181.2ºC |
| Exact Mass | 234.02100 |
| PSA | 86.88000 |
| LogP | 3.86790 |
| Index of Refraction | 1.602 |
| HS Code | 2930909090 |
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Ajoene CAS#:92285-01-3 |
| Literature: DANMARKS TEKNISKE UNIVERSITET; BJARNSHOLT, Thomas; HOEIBY, Niels; JENSEN, Peter OEstrup; PHIPPS, Richard; SHANMUGHAM, Meenakshi Sundaram; GENNIP, Maria van; CHRISTENSEN, Louise Dahl; JAKOBSEN, Tim Holm; TANNER, David; LARSEN, Thomas Ostenfeld; GIVSKOV, Michael Patent: WO2012/76016 A1, 2012 ; Location in patent: Page/Page column 18-19 ; |
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Ajoene CAS#:92285-01-3 |
| Literature: DANMARKS TEKNISKE UNIVERSITET; BJARNSHOLT, Thomas; HOEIBY, Niels; JENSEN, Peter OEstrup; PHIPPS, Richard; SHANMUGHAM, Meenakshi Sundaram; GENNIP, Maria van; CHRISTENSEN, Louise Dahl; JAKOBSEN, Tim Holm; TANNER, David; LARSEN, Thomas Ostenfeld; GIVSKOV, Michael Patent: WO2012/76016 A1, 2012 ; |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| (E,Z)-ajoene |
| 2E,4Z-Heptadienal |
| (E/Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide |
| (E,Z)-2,4-heptadienal |
| 4,5,9-trithiadodeca-1,6,11-triene-9-oxide |
| (Z,E)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide |
| (2E,4Z)-2,4-heptadienal |
| hepta-2t,4c-dienal |
| 2,4-Heptadienal,(E,Z) |