AZD-5597

Modify Date: 2025-08-29 08:25:02

AZD-5597 Structure
AZD-5597 structure
Common Name AZD-5597
CAS Number 924641-59-8 Molecular Weight 437.51
Density N/A Boiling Point N/A
Molecular Formula C23H28FN7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AZD-5597


AZD5597 is an inhibitor of CDK with an IC50 of 2 nM. AZD5597 has potent anti-proliferative effects against a range of cancer cell lines[1].

 Names

Name [4-[[5-fluoro-4-(2-methyl-3-propan-2-ylimidazol-4-yl)pyrimidin-2-yl]amino]phenyl]-[(3S)-3-(methylamino)pyrrolidin-1-yl]methanone
Synonym More Synonyms

 AZD-5597 Biological Activity

Description AZD5597 is an inhibitor of CDK with an IC50 of 2 nM. AZD5597 has potent anti-proliferative effects against a range of cancer cell lines[1].
Related Catalog
Target

IC50: 2 nM (CDK2), 2 nM (CDK1), 39 nM (LoVo)[1]

References

[1]. Jones CD, et al.The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.  

 Chemical & Physical Properties

Molecular Formula C23H28FN7O
Molecular Weight 437.51
Exact Mass 437.23400
PSA 87.97000
LogP 3.94780

 Synonyms

UNII-N7855W19GY
AZD-5597
(S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone
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