Hydroxy-PEG1-C2-methyl ester

Modify Date: 2024-01-12 11:20:59

Hydroxy-PEG1-C2-methyl ester Structure
Hydroxy-PEG1-C2-methyl ester structure
Common Name Hydroxy-PEG1-C2-methyl ester
CAS Number 93673-82-6 Molecular Weight 148.15700
Density N/A Boiling Point N/A
Molecular Formula C6H12O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hydroxy-PEG1-C2-methyl ester


Hydroxy-PEG1-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name methyl 3-(2-hydroxyethoxy)propanoate

 Hydroxy-PEG1-C2-methyl ester Biological Activity

Description Hydroxy-PEG1-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C6H12O4
Molecular Weight 148.15700
Exact Mass 148.07400
PSA 55.76000