HDAC1,2-IN-2
Modify Date: 2025-09-04 10:47:22
HDAC1,2-IN-2 structure
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Common Name | HDAC1,2-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 937727-03-2 | Molecular Weight | 449.529 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC1,2-IN-2A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice. |
| Name | HDAC1,2-IN-2 |
|---|
| Description | A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice. |
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| References | References 1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9. 2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5. View Related Products by Target HDAC |
| Molecular Formula | C23H23N5O3S |
|---|---|
| Molecular Weight | 449.529 |
| InChIKey | MUTPWJCHZIMJSP-UHFFFAOYSA-N |
| SMILES | Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(N2CCC3(CC2)CNC(=O)O3)nc1 |