Tetracaine

Modify Date: 2026-07-01 20:05:37

Tetracaine Structure
Tetracaine structure
Common Name Tetracaine
CAS Number 94-24-6 Molecular Weight 264.363
Density 1.0±0.1 g/cm3 Boiling Point 389.4±27.0 °C at 760 mmHg
Molecular Formula C15H24N2O2 Melting Point 43 °C
MSDS Chinese USA Flash Point 189.3±23.7 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Use of Tetracaine


Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.

Summary: Tetracaine, also known as丁卡因, has a CAS number of 94-24-6, with a molecular formula of C15H24N2O2 and a molecular weight of 264.363. It appears as a white crystalline powder with a melting point of 43 °C and is used for anesthesia. For research-use only, not for medical or clinical usage.


 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name tetracaine
Synonym More Synonyms

 Tetracaine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
Related Catalog

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.0±0.1 g/cm3
Boiling Point 389.4±27.0 °C at 760 mmHg
Melting Point 43 °C
Molecular Formula C15H24N2O2
Molecular Weight 264.363
Flash Point 189.3±23.7 °C
Exact Mass 264.183777
PSA 41.57000
LogP 3.65
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.538

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG4725000
CHEMICAL NAME :
Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
CAS REGISTRY NUMBER :
94-24-6
BEILSTEIN REFERENCE NO. :
2216051
LAST UPDATED :
199612
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C15-H24-N2-O2
MOLECULAR WEIGHT :
264.41
WISWESSER LINE NOTATION :
4MR DVO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Behavioral - coma Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
33500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraspinal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraspinal
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
1 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,205,1965 *** REVIEWS *** TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2779 No. of Facilities: 737 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 18810 (estimated) No. of Female Employees: 13703 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H317-H351
Precautionary Statements P280-P301 + P310
Hazard Codes Xn:Harmful;
Risk Phrases R22;R40;R42/43
Safety Phrases S22-S36/37
RIDADR UN 2811
RTECS DG4725000
HS Code 2922499990

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~94%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: Abdullaev Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 1 p. 28 - 31

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: US1889645 , ;

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

~%

Tetracaine Structure

Tetracaine

CAS#:94-24-6

Learn More
Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles83

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor.

Curr. Eye Res. 40(1) , 56-65, (2014)

We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing.New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soa...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

 TetracaineBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Source: ChEMBL
Target: Delta-type opioid receptor
External Id: CHEMBL1909180
Name: DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-A...
Source: ChEMBL
Target: Nitric oxide synthase, inducible
External Id: CHEMBL1909179
Name: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL1909182
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL1909181
Name: DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909184
Name: pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/04714...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449007
Name: DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909183
Name: DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP)
Source: ChEMBL
Target: cGMP-specific 3',5'-cyclic phosphodiesterase
External Id: CHEMBL1909186
Name: DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL1909185
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
Tetracaina
Tetrakain
Anetain
EINECS 202-316-6
Pontocaine
Dicaine
Contralgin
2-(Dimethylamino)ethyl-4-(butylamino)benzolcarboxylat
Tetracainum
dicaine base
MFCD00053787
Amethocaine
2-(Dimethylamino)ethyl 4-(butylamino)benzoate
Uromucaesthin
Tetracaine

 Tetracaine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of tetracaine?
A: Main uses of tetracaine: Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
Q: What is the safety information for tetracaine?
A: Safety information for tetracaine: S22-S36/37.
Q: What is the melting point of tetracaine?
A: Melting point of tetracaine is 43 °C.
Q: What is the LogP of tetracaine?
A: LogP of tetracaine is 3.65.
Q: What is the boiling point of tetracaine?
A: Boiling point of tetracaine is 389.4±27.0 °C at 760 mmHg.
Q: What is the molecular formula of tetracaine?
A: Molecular formula of tetracaine is C15H24N2O2.
Q: What is the molecular weight of tetracaine?
A: Molecular weight of tetracaine is 264.363.
Q: What are the upstream materials of tetracaine?
A: Related upstream materials(CAS) of tetracaine: 108-01-0;99-77-4;123-72-8;4740-24-3;94-09-7;94-32-6;109-65-9;10012-47-2.
Q: What is the polar surface area (PSA) of tetracaine?
A: Polar surface area (PSA) of tetracaine is 41.57000.
Q: What is the CAS number of tetracaine?
A: CAS number of tetracaine is 94-24-6.

 Tetracainefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Henan Tianfu Chemical Co., Ltd.
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