Tetracaine

Modify Date: 2024-01-02 10:43:03

Tetracaine structure	Common Name	Tetracaine
	CAS Number	94-24-6	Molecular Weight	264.363
	Density	1.0±0.1 g/cm3	Boiling Point	389.4±27.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₄N₂O₂	Melting Point	43 °C
	MSDS	Chinese USA	Flash Point	189.3±23.7 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Tetracaine

Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.

Name	tetracaine
Synonym	More Synonyms

Description	Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease

Density	1.0±0.1 g/cm3
Boiling Point	389.4±27.0 °C at 760 mmHg
Melting Point	43 °C
Molecular Formula	C₁₅H₂₄N₂O₂
Molecular Weight	264.363
Flash Point	189.3±23.7 °C
Exact Mass	264.183777
PSA	41.57000
LogP	3.65
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.538

Tetracaine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG4725000

CHEMICAL NAME :: Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester

CAS REGISTRY NUMBER :: 94-24-6

BEILSTEIN REFERENCE NO. :: 2216051

LAST UPDATED :: 199612

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C15-H24-N2-O2

MOLECULAR WEIGHT :: 264.41

WISWESSER LINE NOTATION :: 4MR DVO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Behavioral - coma Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraspinal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraspinal

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 1 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,205,1965 *** REVIEWS *** TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2779 No. of Facilities: 737 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 18810 (estimated) No. of Female Employees: 13703 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H317-H351
Precautionary Statements	P280-P301 + P310
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R40;R42/43
Safety Phrases	S22-S36/37
RIDADR	UN 2811
RTECS	DG4725000
HS Code	2922499990

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Butyraldehyde

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~94%

Tetracaine

CAS#:94-24-6

Literature: Abdullaev Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 1 p. 28 - 31

2-(Dimethylamin...

CAS#:108-01-0

Benzoic acid, 4...

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Tetracaine

CAS#:94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

Benzocaine

CAS#:94-09-7

Tetracaine

CAS#:94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177

2-(Dimethylamin...

CAS#:108-01-0

Ethyl 4-(butyla...

CAS#:94-32-6

Tetracaine

CAS#:94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

Benzoic acid, 4...

CAS#:4740-24-3

Tetracaine

CAS#:94-24-6

Literature: US1889645 , ;

1-Bromobutane

CAS#:109-65-9

2-(dimethylamin...

CAS#:10012-47-2

Tetracaine

CAS#:94-24-6

Literature: US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536

Ethyl 4-(butyla...

CAS#:94-32-6

Tetracaine

CAS#:94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177

Precursor 8
CAS#:108-01-0 2-(Dimethylamin... CAS#:99-77-4 Ethyl 4-nitrobe... CAS#:123-72-8 Butyraldehyde CAS#:4740-24-3 Benzoic acid, 4...
CAS#:94-09-7 Benzocaine CAS#:94-32-6 Ethyl 4-(butyla... CAS#:109-65-9 1-Bromobutane CAS#:10012-47-2 2-(dimethylamin...
DownStream 0

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor.

Curr. Eye Res. 40(1) , 56-65, (2014)

We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing.New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soa...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester

Tetracaina

Tetrakain

Anetain

EINECS 202-316-6

Pontocaine

Dicaine

Contralgin

2-(Dimethylamino)ethyl-4-(butylamino)benzolcarboxylat

Tetracainum

dicaine base

MFCD00053787

Amethocaine

2-(Dimethylamino)ethyl 4-(butylamino)benzoate

Uromucaesthin

Tetracaine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tetracaine
Price: ￥258.0/5g ￥608.0/25g
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Tetracaine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Tetracaine;Anetain
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Tetracaine

Use of Tetracaine

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Tetracaine Biological Activity

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MSDS

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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