OUL232
Modify Date: 2024-04-09 17:35:39
OUL232 structure
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Common Name | OUL232 | ||
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| CAS Number | 943119-42-4 | Molecular Weight | 250.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H10N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OUL232OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1]. |
| Name | OUL232 |
|---|
| Description | OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1]. |
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| Related Catalog | |
| Target |
PARP7:83 nM (IC50) PARP10:7.8 nM (IC50) PARP14:300 nM (IC50) PARP15:56 nM (IC50) PARP1:15 μM (IC50) PARP2:10 μM (IC50) PARP3:50 μM (IC50) PARP4:11 μM (IC50) TNKS1:5.4 μM (IC50) TNKS2:10 μM (IC50) PARP11:240 nM (IC50) PARP12:160 nM (IC50) PARP16:3.4 μM (IC50) |
| In Vitro | OUL232 (化合物 27) (1 μM; 10-12 d) 拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡[1]。 药代动力学分析[1] water solubility μg/mL GI Papp×10-6 cm/s (RM %) BBB Papp×10-6 cm/s (RM %) metabolic stablity % stab in human plasma stab. in MeOH stab in PBS pH 7.4 12.60 0.144 0.143 99.11 >24 >24 >24 |
| References |
| Molecular Formula | C10H10N4O2S |
|---|---|
| Molecular Weight | 250.28 |