943119-42-4
943119-42-4 structure
- Name: OUL232
- Chemical Name: OUL232
- CAS Number: 943119-42-4
- Molecular Formula: C10H10N4O2S
- Molecular Weight: 250.28
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2023-04-05 18:03:39
- Modify Date: 2025-08-25 17:40:33
-
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1].
| Name | OUL232 |
|---|
| Description | OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1]. |
|---|---|
| Related Catalog | |
| Target |
PARP7:83 nM (IC50) PARP10:7.8 nM (IC50) PARP14:300 nM (IC50) PARP15:56 nM (IC50) PARP1:15 μM (IC50) PARP2:10 μM (IC50) PARP3:50 μM (IC50) PARP4:11 μM (IC50) TNKS1:5.4 μM (IC50) TNKS2:10 μM (IC50) PARP11:240 nM (IC50) PARP12:160 nM (IC50) PARP16:3.4 μM (IC50) |
| In Vitro | OUL232 (化合物 27) (1 μM; 10-12 d) 拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡[1]。 药代动力学分析[1] water solubility μg/mL GI Papp×10-6 cm/s (RM %) BBB Papp×10-6 cm/s (RM %) metabolic stablity % stab in human plasma stab. in MeOH stab in PBS pH 7.4 12.60 0.144 0.143 99.11 >24 >24 >24 |
| References |
| Molecular Formula | C10H10N4O2S |
|---|---|
| Molecular Weight | 250.28 |