ACA-28

Modify Date: 2025-08-21 18:26:57

ACA-28 Structure
ACA-28 structure
 Common Name ACA-28
CAS Number 948044-25-5 Molecular Weight 316.31
Density N/A Boiling Point N/A
Molecular Formula C17H16O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACA-28


ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivationACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1].

 Names

Name ACA-28

 ACA-28 Biological Activity

Description ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivationACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1].
Related Catalog
References

[1]. Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137.

 Chemical & Physical Properties

Molecular Formula C17H16O6
Molecular Weight 316.31
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Chemsrc provides ACA-28(CAS#:948044-25-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ACA-28 are included as well.>> amp version: ACA-28

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