H-Gly-Gly-Cys-OH

Modify Date: 2024-01-14 16:50:04

H-Gly-Gly-Cys-OH Structure
H-Gly-Gly-Cys-OH structure
Common Name H-Gly-Gly-Cys-OH
CAS Number 95416-30-1 Molecular Weight 235.26
Density N/A Boiling Point N/A
Molecular Formula C7H13N3O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-Gly-Gly-Cys-OH


Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a Ki of 0.99 μM and a IC50 of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin[1].

 Names

Name (2R)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-sulfanylpropanoic acid
Synonym More Synonyms

 H-Gly-Gly-Cys-OH Biological Activity

Description Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a Ki of 0.99 μM and a IC50 of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin[1].
Related Catalog
Target

IC50: 9.4 μM (TAFI) Ki: 0.99 μM (TAFI)[1]

References

[1]. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71.  

 Chemical & Physical Properties

Molecular Formula C7H13N3O4S
Molecular Weight 235.26
Exact Mass 235.06300
PSA 167.30000

 Synonyms

Glycyl-glycyl-cysteine
Gly-gly-cys