H-Gly-Arg-Gly-Asp-Ser-OH

Modify Date: 2025-08-22 18:22:11

H-Gly-Arg-Gly-Asp-Ser-OH Structure
H-Gly-Arg-Gly-Asp-Ser-OH structure
 Common Name H-Gly-Arg-Gly-Asp-Ser-OH
CAS Number 96426-21-0 Molecular Weight 490.46800
Density 1.66 g/cm3 Boiling Point N/A
Molecular Formula C17H30N8O9 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of H-Gly-Arg-Gly-Asp-Ser-OH


Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.

 Names

Name gly-arg-gly-asp-ser
Synonym More Synonyms

 H-Gly-Arg-Gly-Asp-Ser-OH Biological Activity

Description Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.
Related Catalog
In Vitro Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. GRGDS-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2].
References

[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.

[2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

 Chemical & Physical Properties

Density 1.66 g/cm3
Molecular Formula C17H30N8O9
Molecular Weight 490.46800
Exact Mass 490.21400
PSA 299.15000
Index of Refraction 1.664

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synthetic Route

N/A structure

N/A

CAS#:132304-02-0

~%

H-Gly-Arg-Gly-Asp-Ser-OH Structure

H-Gly-Arg-Gly-A...

CAS#:96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713
N-((S)-2-(2-((S)-2-(2-aminoacetamido)-5-(3-(mesitylsulfonyl)guanidino)pentanamido)acetamido)-4-(cyclohexyloxy)-4-oxobutanoyl)-O-benzyl-L-serine structure

N-((S)-2-(2-((S...

CAS#:132304-03-1

~%

H-Gly-Arg-Gly-Asp-Ser-OH Structure

H-Gly-Arg-Gly-A...

CAS#:96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713
N/A structure

N/A

CAS#:132304-04-2

~%

H-Gly-Arg-Gly-Asp-Ser-OH Structure

H-Gly-Arg-Gly-A...

CAS#:96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713

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 Synonyms

Gly-Arg-Gly-Asp-Ser-OH
GRGDS 1/2ACOH 2H2O
H-GLY-ARG-GLY-ASP-SER-OH
GRGDS
GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE
glycyl-arginyl-glycyl-aspartyl-serine
MFCD00076459
L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl
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