Ditolylguanidine

Modify Date: 2026-07-02 18:40:35

Ditolylguanidine structure	Common Name	Ditolylguanidine
	CAS Number	97-39-2	Molecular Weight	239.32
	Density	1.1±0.1 g/cm3	Boiling Point	396.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₇N₃	Melting Point	176-178 °C(lit.)
	MSDS	Chinese USA	Flash Point	193.3±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Ditolylguanidine

Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1,3-Di-o-tolylguanidine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Sigma receptor[1]
References	[1]. Skuza G, et al. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	396.1±45.0 °C at 760 mmHg
Melting Point	176-178 °C(lit.)
Molecular Formula	C₁₅H₁₇N₃
Molecular Weight	239.32
Flash Point	193.3±28.7 °C
Exact Mass	239.142242
PSA	47.91000
LogP	3.77
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.585
InChIKey	OPNUROKCUBTKLF-UHFFFAOYSA-N
SMILES	Cc1ccccc1N=C(N)Nc1ccccc1C
Storage condition	Store at RT

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Ditolylguanidine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF1400000

CHEMICAL NAME :: Guanidine, 1,3-di-o-tolyl-

CAS REGISTRY NUMBER :: 97-39-2

BEILSTEIN REFERENCE NO. :: 2653884

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H17-N3

MOLECULAR WEIGHT :: 239.35

WISWESSER LINE NOTATION :: 1R BMYUM&MR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81800 No. of Facilities: 157 (estimated) No. of Industries: 5 No. of Occupations: 23 No. of Employees: 3729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81800 No. of Facilities: 492 (estimated) No. of Industries: 7 No. of Occupations: 18 No. of Employees: 22254 (estimated) No. of Female Employees: 4255 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	UN 2811
WGK Germany	3
RTECS	MF1400000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2925290090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:615-37-2 4-Iodotoluene CAS#:506-93-4 Guanidine nitrate CAS#:124-46-9 carbonic acid; ... CAS#:646-34-4 guanidine
CAS#:95-46-5 2-Bromotoluene CAS#:22695-18-7 N,N-di-o-tolylt... CAS#:95-53-4 o-Toluidine CAS#:506-77-4 Cyanogen chloride
CAS#:137-97-3 1,3-di(o-tolyl)... CAS#:7664-41-7 Ammonia
DownStream 3
CAS#:3467-29-6 3H-1,2-Dithiole... CAS#:4132-53-0 4-(4-(tert-buty... CAS#:7783-06-4 hydrogen sulfide

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination.

J. Neurosci. Res. 93(2) , 285-95, (2014)

The γ-aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To inve...

Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice.

Neurobiol. Aging 36 , 1820-33, (2015)

Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been ad...

Monodisperse silica nanoparticles coated with gold nanoparticles as a sorbent for the extraction of phenol and dihydroxybenzenes from water samples based on dispersive micro-solid-phase extraction: Response surface methodology.

J. Sep. Sci. 38 , 2804-12, (2015)

A selective and sensitive method was developed based on dispersive micro-solid-phase extraction for the extraction of hydroquinone, resorcinol, pyrocatechol and phenol from water samples prior to high...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Selectivity ratio of Ki for sigma 1 receptor in guinea pig brain membranes to Ki for ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1775706

Name: Inhibition of electrically stimulated contractions of the isolated guinea pig badder.
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL684565

Name: Displacement of [3H]DTG from sigma 2 receptor in Wistar Hannover rat liver membrane b...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2349697

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: Displacement of [3H]di-o-tolylguanidine from sigma 2 receptor in rat liver membranes ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3784256

Name: Displacement of (+)-[3H]pentazocine from guinea pig brain sigma 1 receptor after 180 ...
Source: ChEMBL
Target: Sigma non-opioid intracellular receptor 1
External Id: CHEMBL1833395

Name: Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membran...
Source: ChEMBL
Target: Sigma non-opioid intracellular receptor 1
External Id: CHEMBL3783729

Name: Selectivity ratio of Ki for guinea pig brain sigma 1 receptor to Ki for rat liver sig...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1833397

Total 574, Current Page 1 of 58

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00008513

1,3-Bis(o-tolyl)guanidine

N,N'-Di-o-tolylguanidine

EINECS 202-577-6

N,N'-Bis(2-methylphenyl)guanidine

Di-o-tolylguanidine

1R BMYUM&MR B1

1,2-Bis(2-methylphenyl)guanidine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does 1,3-Di-o-tolylguanidine have?

A: English synonyms of 1,3-Di-o-tolylguanidine: MFCD00008513, 1,3-Bis(o-tolyl)guanidine, N,N'-Di-o-tolylguanidine, EINECS 202-577-6, N,N'-Bis(2-methylphenyl)guanidine, Di-o-tolylguanidine, 1R BMYUM&MR B1, 1,2-Bis(2-methylphenyl)guanidine.

Q: What is the LogP of 1,3-Di-o-tolylguanidine?

A: LogP of 1,3-Di-o-tolylguanidine is 3.77.

Q: What are the upstream materials of 1,3-Di-o-tolylguanidine?

A: Related upstream materials(CAS) of 1,3-Di-o-tolylguanidine: 615-37-2;506-93-4;124-46-9;646-34-4;95-46-5;22695-18-7;95-53-4;506-77-4;137-97-3;7664-41-7.

Q: What is the molecular weight of 1,3-Di-o-tolylguanidine?

A: Molecular weight of 1,3-Di-o-tolylguanidine is 239.32.

Q: What is the InChIKey of 1,3-Di-o-tolylguanidine?

A: InChIKey of 1,3-Di-o-tolylguanidine is OPNUROKCUBTKLF-UHFFFAOYSA-N.

Q: What is the safety information for 1,3-Di-o-tolylguanidine?

A: Safety information for 1,3-Di-o-tolylguanidine: S26-S36.

Q: What is the boiling point of 1,3-Di-o-tolylguanidine?

A: Boiling point of 1,3-Di-o-tolylguanidine is 396.1±45.0 °C at 760 mmHg.

Q: What are the downstream products of 1,3-Di-o-tolylguanidine?

A: Related downstream products(CAS) of 1,3-Di-o-tolylguanidine: 3467-29-6;4132-53-0;7783-06-4.

Q: What is the SMILES notation of 1,3-Di-o-tolylguanidine?

A: SMILES notation of 1,3-Di-o-tolylguanidine is Cc1ccccc1N=C(N)Nc1ccccc1C.

Q: What are the storage conditions for 1,3-Di-o-tolylguanidine?

A: Storage conditions for 1,3-Di-o-tolylguanidine: Store at RT.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ditolylguanidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Ditolylguanidine
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

Ditolylguanidine suppliers

Price: ￥390/100g

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Ditolylguanidine

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