4-Nitro-o-anisidine

Modify Date: 2026-06-30 11:42:20

4-Nitro-o-anisidine Structure
4-Nitro-o-anisidine structure
 Common Name 4-Nitro-o-anisidine
CAS Number 97-52-9 Molecular Weight 168.150
Density 1.3±0.1 g/cm3 Boiling Point 364.2±22.0 °C at 760 mmHg
Molecular Formula C7H8N2O3 Melting Point 140-142 °C(lit.)
MSDS Chinese USA Flash Point 174.0±22.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-Methoxy-4-nitroaniline
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.3±0.1 g/cm3
Boiling Point 364.2±22.0 °C at 760 mmHg
Melting Point 140-142 °C(lit.)
Molecular Formula C7H8N2O3
Molecular Weight 168.150
Flash Point 174.0±22.3 °C
Exact Mass 168.053497
PSA 81.07000
LogP 1.85
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.601
InChIKey GVBHRNIWBGTNQA-UHFFFAOYSA-N
SMILES COc1cc([N+](=O)[O-])ccc1N
Water Solubility slightly soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ7170000
CHEMICAL NAME :
o-Anisidine, 4-nitro-
CAS REGISTRY NUMBER :
97-52-9
BEILSTEIN REFERENCE NO. :
0879619
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H8-N2-O3
MOLECULAR WEIGHT :
168.17
WISWESSER LINE NOTATION :
WNR DZ C01

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
997 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,717,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0147 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 523 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0147 No. of Facilities: 70 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 198 (estimated) No. of Female Employees: 80 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S26-S37/39-S36/37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS BZ7170000
Hazard Class 6.1
HS Code 29222900

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles3

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver.

Cancer Lett. 96(1) , 95-8, (1995)

Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidat...

Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice.

Xenobiotica 42(12) , 1213-24, (2012)

The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2...

Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations. Leonardo SG, et al.

Anal. Methods 3(5) , 1198-1201, (2011)

 4-Nitro-o-anisidineBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-METHOXY-4-NITROANILINE/4-NITRO-O-ANISIDINE
EINECS 202-588-6
2-Amino-5-nitroanisole
2-amino-5-nitroanisol
2-methoxy-4nitro-aniline
4-Nitro-o-anisidine
KERNECHTROT SALT B
2-Methoxy-4-nitrobenzenamine
2-METHOXY-4-NITRO-ANILINE 97-52-9
2-Methoxy-4-nitroaniline
2-METHOXY-4-NITROANILINE FOR SYNTHESIS
Red B Base
2-methoxy-4-nitrophenylamine
1-amino-2-methoxy-4-nitrobenzene
Fast Red B
2-Amino-1-methoxy-5-nitrobenzene
2-METHOXY-4-NITROANILIN
4-Nitro-6-methoxyaniline
5-nitro-2-amino-1-methoxy-benzene
Fast Red Base B
Benzenamine,2-methoxy-4-nitro
o-Anisidine,4-nitro
2-METHOXY-4-NITRO ANILINE
5-Nitro-2-anisidine
5-nitro-2-amino-anisole
MFCD00007363
4-Amino-3-methoxynitrobenzene
4-NITRO-O-ANISIDINE (NH2=1)
Fast Red B Base
FASTREDBBASE

 4-Nitro-o-anisidine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of 2-Methoxy-4-nitroaniline?
A: Molecular weight of 2-Methoxy-4-nitroaniline is 168.150.
Q: What is the LogP of 2-Methoxy-4-nitroaniline?
A: LogP of 2-Methoxy-4-nitroaniline is 1.85.
Q: What is the safety information for 2-Methoxy-4-nitroaniline?
A: Safety information for 2-Methoxy-4-nitroaniline: S26-S37/39-S36/37.
Q: What is the boiling point of 2-Methoxy-4-nitroaniline?
A: Boiling point of 2-Methoxy-4-nitroaniline is 364.2±22.0 °C at 760 mmHg.
Q: How is the water solubility of 2-Methoxy-4-nitroaniline?
A: Water solubility of 2-Methoxy-4-nitroaniline: slightly soluble.
Q: What are the downstream products of 2-Methoxy-4-nitroaniline?
A: Related downstream products(CAS) of 2-Methoxy-4-nitroaniline: 110506-34-8;110506-18-8;3251-56-7;555-03-3;33484-67-2;454-16-0;81721-86-0;93-50-5;198821-78-2;5458-84-4.
Q: What is the CAS number of 2-Methoxy-4-nitroaniline?
A: CAS number of 2-Methoxy-4-nitroaniline is 97-52-9.
Q: What are the upstream materials of 2-Methoxy-4-nitroaniline?
A: Related upstream materials(CAS) of 2-Methoxy-4-nitroaniline: 869373-61-5;5720-07-0;555-03-3;869373-72-8;5720-05-8;93-26-5;74-88-4;121-88-0;50625-30-4.
Q: What is the melting point of 2-Methoxy-4-nitroaniline?
A: Melting point of 2-Methoxy-4-nitroaniline is 140-142 °C(lit.).
Q: What is the polar surface area (PSA) of 2-Methoxy-4-nitroaniline?
A: Polar surface area (PSA) of 2-Methoxy-4-nitroaniline is 81.07000.

 4-Nitro-o-anisidinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides 4-Nitro-o-anisidine(CAS#:97-52-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4-Nitro-o-anisidine are included as well.>> amp version: 4-Nitro-o-anisidine

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