Reboxetine (mesylate)
Modify Date: 2025-08-27 11:40:12
Reboxetine (mesylate) structure
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Common Name | Reboxetine (mesylate) | ||
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| CAS Number | 98769-84-7 | Molecular Weight | 409.496 | |
| Density | N/A | Boiling Point | 443.7ºC at 760 mmHg | |
| Molecular Formula | C20H27NO6S | Melting Point | 170-171ºC | |
| MSDS | N/A | Flash Point | 188.2ºC | |
Use of Reboxetine (mesylate)Reboxetine Mesylate is a norepinephrine reuptake inhibitor use in the treatment of unipolar depression.Target: OthersReboxetine is a drug of the norepinephrine reuptake inhibitor class. Reboxetine dose-dependently and potently inhibits locus coeruleus neuronal firing in rats with ED50 of 191 μg/kg. Reboxetine inhibition of the locus coeruleus neurons is reversible by the α2 antagonist piperoxan (1.5 mg/kg, IV). Reboxetine dose-dependently reverses reserpine-induced blepharospasm and hypothermia in the mouse. Reboxetine is also found to antagonize clonidine-induced hypothermia dose-dependently in mice. Reboxetine reverses reserpine-induced blepharospasm and hypothermia in rats with ED50 of 10 mg/kg and 3 mg/kg (p.o.), respectively [1]. Reboxetine is associated with a markedly lower relapse rate than placebo (22% vs. 56%) and a greater cumulative probability of a maintained response during long-term treatment in patients with recurrent DSM-III-R major depression. Reboxetine effectively prevents recurrence of depressive symptoms following episode resolution [2]. Acute systemic administration of Reboxetine (0.3 mg/kg-20 mg/kg) dose-dependently increases extracellular norepinephrine in the rat frontal cortex while having no effect on extracellular serotonin. Reboxetine (20 mg/kg) also increases extracellular dopamine in the rat frontal cortex. Chronic administration of Reboxetine for 14 days results in elevated basal concentrations of extracellular norepinephrine and dopamine and a greater net increase of extracellular norepinephrine and dopamine, but not serotonin in the rat frontal cortex [3]. |
| Name | Reboxetine mesylate |
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| Synonym | More Synonyms |
| Description | Reboxetine Mesylate is a norepinephrine reuptake inhibitor use in the treatment of unipolar depression.Target: OthersReboxetine is a drug of the norepinephrine reuptake inhibitor class. Reboxetine dose-dependently and potently inhibits locus coeruleus neuronal firing in rats with ED50 of 191 μg/kg. Reboxetine inhibition of the locus coeruleus neurons is reversible by the α2 antagonist piperoxan (1.5 mg/kg, IV). Reboxetine dose-dependently reverses reserpine-induced blepharospasm and hypothermia in the mouse. Reboxetine is also found to antagonize clonidine-induced hypothermia dose-dependently in mice. Reboxetine reverses reserpine-induced blepharospasm and hypothermia in rats with ED50 of 10 mg/kg and 3 mg/kg (p.o.), respectively [1]. Reboxetine is associated with a markedly lower relapse rate than placebo (22% vs. 56%) and a greater cumulative probability of a maintained response during long-term treatment in patients with recurrent DSM-III-R major depression. Reboxetine effectively prevents recurrence of depressive symptoms following episode resolution [2]. Acute systemic administration of Reboxetine (0.3 mg/kg-20 mg/kg) dose-dependently increases extracellular norepinephrine in the rat frontal cortex while having no effect on extracellular serotonin. Reboxetine (20 mg/kg) also increases extracellular dopamine in the rat frontal cortex. Chronic administration of Reboxetine for 14 days results in elevated basal concentrations of extracellular norepinephrine and dopamine and a greater net increase of extracellular norepinephrine and dopamine, but not serotonin in the rat frontal cortex [3]. |
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| Related Catalog | |
| References |
| Boiling Point | 443.7ºC at 760 mmHg |
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| Melting Point | 170-171ºC |
| Molecular Formula | C20H27NO6S |
| Molecular Weight | 409.496 |
| Flash Point | 188.2ºC |
| Exact Mass | 409.155914 |
| PSA | 102.47000 |
| LogP | 4.10740 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: ~8 mg/mL at ≤60 °C |
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
| Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-, methanesulfonate (1:1) |
| REBOXETINE MESYLATE HYDRATE |
| REBOXETINE,MESYLATE |
| (2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine |
| EDRONAX |
| VESTRA |
| (2R)-2-[(R)-(2-Ethoxyphenoxy)(phenyl)methyl]morpholine methanesulfonate (1:1) |
| REBOXETINE, MESYLATE |
| Reboxetine (mesylate) |
| REBOXETINE MESILATE |
| Reboxetine hydrate mesylate |
| Reboxetinemesylate |
| (±)-(2R*)-2-[(aR*)-a-(o-Ethoxyphenoxy)benzyl]morpholine Methanesulfonate |
| RAC-N-BENZYL-N-[2-HYDROXYL-2-(4-BENZYLOXY-3-FORMAMIDOPHENYL)-ETHYL]-3-(4-METHOXYPHENYL)-2-PROPYLAMINE-D6 |
| MFCD02184016 |
| REBOXETIN MESYLATE |
| 2-[(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate |