(R)-(+)-Bay K 8644
Modify Date: 2024-01-12 10:27:31
(R)-(+)-Bay K 8644 structure
|
Common Name | (R)-(+)-Bay K 8644 | ||
|---|---|---|---|---|
| CAS Number | 98791-67-4 | Molecular Weight | 356.297 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 429.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H15F3N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 213.4±28.7 °C | |
Use of (R)-(+)-Bay K 8644Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). |
| Name | r(+)-bay k 8644 |
|---|---|
| Synonym | More Synonyms |
| Description | Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). |
|---|---|
| Related Catalog | |
| Target |
IC50: 975 nM (IBa)[1] |
| In Vitro | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa[1]. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 429.2±45.0 °C at 760 mmHg |
| Molecular Formula | C16H15F3N2O4 |
| Molecular Weight | 356.297 |
| Flash Point | 213.4±28.7 °C |
| Exact Mass | 356.098389 |
| PSA | 84.15000 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate |
| (±)-Bay K8644 |
| Bay K 8644 |
| Methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate |
| Bay K 8644,(±)- |
| methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate |
| (±)-Bay K 8644 |
| 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester |
| Methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate |
| (R)-Bay-K-8644 |
| 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)- |
| Bay K8644 |
| Bay-K-8644 ((R)-(+)-) |