(S)-(-)-Bay K 8644

Modify Date: 2024-01-13 23:21:19

(S)-(-)-Bay K 8644 structure	Common Name	(S)-(-)-Bay K 8644
	CAS Number	98625-26-4	Molecular Weight	356.29700
	Density	1.37g/cm3	Boiling Point	429.2ºC at 760mmHg
	Molecular Formula	C₁₆H₁₅F₃N₂O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	213.4ºC
	Symbol	GHS07	Signal Word	Warning

Use of (S)-(-)-Bay K 8644

Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

Name	methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Synonym	More Synonyms

Description	Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	EC50: 32 nM (IBa)[1]
In Vitro	(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[1]. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels[2]. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176[3].
References	[1]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. [2]. Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87. [3]. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602.

Density	1.37g/cm3
Boiling Point	429.2ºC at 760mmHg
Molecular Formula	C₁₆H₁₅F₃N₂O₄
Molecular Weight	356.29700
Flash Point	213.4ºC
Exact Mass	356.09800
PSA	84.15000
LogP	4.19940

(S)-(-)-Bay K 8644 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

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Tocris-1544

(S)-(-)-Bay K8644

Lopac-B-112

S-(-)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Bay-K-8644 ((S)-(-)-)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S)-(-)-Bay K 8644
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
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DC Chemicals Limited
China
Product Name: (S)-(-)-Bay K8644
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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