(S)-(-)-Bay K 8644
(S)-(-)-Bay K 8644 structure
|
Common Name | (S)-(-)-Bay K 8644 | ||
|---|---|---|---|---|
| CAS Number | 98625-26-4 | Molecular Weight | 356.29700 | |
| Density | 1.37g/cm3 | Boiling Point | 429.2ºC at 760mmHg | |
| Molecular Formula | C16H15F3N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 213.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of (S)-(-)-Bay K 8644Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM). |
| Name | methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM). |
|---|---|
| Related Catalog | |
| Target |
EC50: 32 nM (IBa)[1] |
| In Vitro | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[1]. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels[2]. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176[3]. |
| References |
| Density | 1.37g/cm3 |
|---|---|
| Boiling Point | 429.2ºC at 760mmHg |
| Molecular Formula | C16H15F3N2O4 |
| Molecular Weight | 356.29700 |
| Flash Point | 213.4ºC |
| Exact Mass | 356.09800 |
| PSA | 84.15000 |
| LogP | 4.19940 |
| InChIKey | ZFLWDHHVRRZMEI-ZDUSSCGKSA-N |
| SMILES | COC(=O)C1=C(C)NC(C)=C([N+](=O)[O-])C1c1ccccc1C(F)(F)F |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| RIDADR | NONH for all modes of transport |
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Identification and mechanosensitivity of viscerofugal neurons.
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| Tocris-1544 |
| (S)-(-)-Bay K8644 |
| Lopac-B-112 |
| S-(-)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester |
| Bay-K-8644 ((S)-(-)-) |