Lymecycline

Modify Date: 2025-08-25 15:46:55

Lymecycline Structure
Lymecycline structure
Common Name Lymecycline
CAS Number 992-21-2 Molecular Weight 602.63
Density 1.53 Boiling Point 840.5ºC at 760 mmHg
Molecular Formula C29H38N4O10 Melting Point 192.5°C
MSDS N/A Flash Point 462.1ºC

 Use of Lymecycline


Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property.

 Names

Name lymecycline
Synonym More Synonyms

 Lymecycline Biological Activity

Description Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property.
Related Catalog
Target

Bacterial[1]

In Vitro Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity interfering with prokaryotic protein synthesis at the ribosome level. Lymecycline also has anti-inflammatory property[1].
References

[1]. Rempe S, et al. Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6.  

 Chemical & Physical Properties

Density 1.53
Boiling Point 840.5ºC at 760 mmHg
Melting Point 192.5°C
Molecular Formula C29H38N4O10
Molecular Weight 602.63
Flash Point 462.1ºC
Exact Mass 602.25900
PSA 242.98000
LogP 1.02790
Index of Refraction 1.693
Water Solubility Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL5615000
CHEMICAL NAME :
Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)-
CAS REGISTRY NUMBER :
992-21-2
LAST UPDATED :
199201
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H38-N4-O10
MOLECULAR WEIGHT :
602.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
181 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
253 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964

 LymecyclineBioassay

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Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791
Name: Binding affinity towards human HRH3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Histamine H3 receptor
External Id: CHEMBL5291921
Name: Choleostatic liver toxicity, either proven histopathologically or where the ratio of ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137727
Name: Severe hepatitis, defined as possibly life-threatening liver failure or through clini...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137728
Name: Chronic liver disease either proven histopathologically, or through a chonic elevatio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137729
Name: Cirrhosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137730
Name: Granulomatous liver disease, proven histopathologically. Value is number of reference...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3137731
Name: Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137732
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 Synonyms

limecycline
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate
2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester
lycopsamine
(+)-Indicine
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