RO 19-4603

Modify Date: 2024-03-03 19:10:57

RO 19-4603 structure	Common Name	RO 19-4603
	CAS Number	99632-94-7	Molecular Weight	319.38
	Density	1.37g/cm3	Boiling Point	537.7ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	279ºC

Use of RO 19-4603

Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].

Name	tert.-butyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate
Synonym	More Synonyms

Description	Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	Ro19-4603 (0-0.3 mg/kg，腹腔注射) 显着降低嗜酒大鼠在 8 小时间隔内的乙醇摄入量[1]。 Animal Model: Alcohol-Preferring rats[1] Dosage: 0.075, 0.150, and 0.30 mg/kg. Administration: i.p. Result: Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval.
References	[1]. June HL, et al. The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology (Berl). 1994 Jul;115(3):325-31.

Density	1.37g/cm3
Boiling Point	537.7ºC at 760 mmHg
Molecular Formula	C₁₅H₁₇N₃O₃S
Molecular Weight	319.38
Flash Point	279ºC
Exact Mass	319.09900
PSA	92.67000
LogP	2.41260
Index of Refraction	1.659

Tocris-1995