Saccharopine
Saccharopine structure
|
Common Name | Saccharopine | ||
|---|---|---|---|---|
| CAS Number | 997-68-2 | Molecular Weight | 276.28600 | |
| Density | 1.333g/cm3 | Boiling Point | 537.2ºC at 760mmHg | |
| Molecular Formula | C11H20N2O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 278.7ºC | |
Use of SaccharopineSaccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | L-saccharopine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1]. |
| In Vivo | Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.333g/cm3 |
|---|---|
| Boiling Point | 537.2ºC at 760mmHg |
| Molecular Formula | C11H20N2O6 |
| Molecular Weight | 276.28600 |
| Flash Point | 278.7ºC |
| Exact Mass | 276.13200 |
| PSA | 149.95000 |
| LogP | 0.56740 |
| Index of Refraction | 1.537 |
| InChIKey | ZDGJAHTZVHVLOT-YUMQZZPRSA-N |
| SMILES | NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922499990 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:56-87-1
CAS#:64-15-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine.
Mol. Cell Biochem. 410 , 93-100, (2015) Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the eff... |
|
|
Molecular cloning and expression of human L-pipecolate oxidase.
Biochem. Biophys. Res. Commun. 270(3) , 1101-5, (2000) In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of l... |
|
|
Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta.
Exp. Parasitol. 131(1) , 101-6, (2012) Catabolism of lysine through the pipecolate, saccharopine and cadaverine pathways has been investigated in L3 and adult Haemonchus contortus and Teladorsagia circumcincta. Both enzymes of the saccharo... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| L-SACCHAROPINE |
| L-Saccharopine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of L-saccharopine? |
| A: Boiling point of L-saccharopine is 537.2ºC at 760mmHg. |
| Q: What is the polar surface area (PSA) of L-saccharopine? |
| A: Polar surface area (PSA) of L-saccharopine is 149.95000. |
| Q: What is the SMILES notation of L-saccharopine? |
| A: SMILES notation of L-saccharopine is NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O. |
| Q: What are the downstream products of L-saccharopine? |
| A: Related downstream products(CAS) of L-saccharopine: 56-87-1;64-15-3. |
| Q: What English synonyms does L-saccharopine have? |
| A: English synonyms of L-saccharopine: L-SACCHAROPINE, L-Saccharopine. |
| Q: What is the LogP of L-saccharopine? |
| A: LogP of L-saccharopine is 0.56740. |
| Q: What is the molecular formula of L-saccharopine? |
| A: Molecular formula of L-saccharopine is C11H20N2O6. |
| Q: What is the InChIKey of L-saccharopine? |
| A: InChIKey of L-saccharopine is ZDGJAHTZVHVLOT-YUMQZZPRSA-N. |
| Q: What is the CAS number of L-saccharopine? |
| A: CAS number of L-saccharopine is 997-68-2. |
| Q: What is the molecular weight of L-saccharopine? |
| A: Molecular weight of L-saccharopine is 276.28600. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |