Saccharopine

Modify Date: 2025-08-23 22:44:17

Saccharopine structure	Common Name	Saccharopine
	CAS Number	997-68-2	Molecular Weight	276.28600
	Density	1.333g/cm3	Boiling Point	537.2ºC at 760mmHg
	Molecular Formula	C₁₁H₂₀N₂O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	278.7ºC

Use of Saccharopine

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3].

Name	L-saccharopine
Synonym	More Synonyms

Description	Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1].
In Vivo	Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1].
References	[1]. Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218(2):580-597. [2]. Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218(2):391-392. [3]. Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):555-63.

Density	1.333g/cm3
Boiling Point	537.2ºC at 760mmHg
Molecular Formula	C₁₁H₂₀N₂O₆
Molecular Weight	276.28600
Flash Point	278.7ºC
Exact Mass	276.13200
PSA	149.95000
LogP	0.56740
Index of Refraction	1.537
InChIKey	ZDGJAHTZVHVLOT-YUMQZZPRSA-N
SMILES	NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O

Saccharopine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922499990

Precursor 0
DownStream 2
CAS#:56-87-1 L-Lysine CAS#:64-15-3 2-oxoglutarate(2-)

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine.

Mol. Cell Biochem. 410 , 93-100, (2015)

Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the eff...

Molecular cloning and expression of human L-pipecolate oxidase.

Biochem. Biophys. Res. Commun. 270(3) , 1101-5, (2000)

In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of l...

Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta.

Exp. Parasitol. 131(1) , 101-6, (2012)

Catabolism of lysine through the pipecolate, saccharopine and cadaverine pathways has been investigated in L3 and adult Haemonchus contortus and Teladorsagia circumcincta. Both enzymes of the saccharo...

L-SACCHAROPINE

L-Saccharopine