Hexamethyldisilazane

Modify Date: 2025-08-20 10:19:02

Hexamethyldisilazane Structure
Hexamethyldisilazane structure
 Common Name Hexamethyldisilazane
CAS Number 999-97-3 Molecular Weight 161.393
Density 0.8±0.1 g/cm3 Boiling Point 126.0±9.0 °C at 760 mmHg
Molecular Formula C6H19NSi2 Melting Point -78 °C
MSDS Chinese USA Flash Point 30.0±18.7 °C
Symbol GHS02 GHS06
GHS02, GHS06		 Signal Word Danger

 Names

Name hexamethyldisilazane
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.8±0.1 g/cm3
Boiling Point 126.0±9.0 °C at 760 mmHg
Melting Point -78 °C
Molecular Formula C6H19NSi2
Molecular Weight 161.393
Flash Point 30.0±18.7 °C
Exact Mass 161.105606
PSA 12.03000
LogP 2.32
Vapour Pressure 11.9±0.2 mmHg at 25°C
Index of Refraction 1.404
InChIKey FFUAGWLWBBFQJT-UHFFFAOYSA-N
SMILES C[Si](C)(C)N[Si](C)(C)C
Water Solubility REACTS

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JM9230000
CHEMICAL NAME :
Disilazane, 1,1,1,3,3,3-hexamethyl-
CAS REGISTRY NUMBER :
999-97-3
LAST UPDATED :
199710
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C6-H19-N-Si2
MOLECULAR WEIGHT :
161.44
WISWESSER LINE NOTATION :
1-SI-1&1&M-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533941 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8700 mg/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle weakness Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0537734
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/m3/2H
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 Volume(issue)/page/year: 17JUN1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
710 uL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,576,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 mL/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle weakness Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0537734 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
98 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(5),52,1986 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,495,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4131 No. of Facilities: 220 (estimated) No. of Industries: 10 No. of Occupations: 22 No. of Employees: 30908 (estimated) No. of Female Employees: 4223 (estimated)

 Safety Information

Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger
Hazard Statements H225-H302 + H332-H311-H412
Precautionary Statements P210-P261-P273-P280-P302 + P352 + P312-P304 + P340 + P312
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive
Risk Phrases R11;R20/21/22;R34
Safety Phrases S16-S26-S36/37/39-S45
RIDADR UN 3286 3/PG 2
WGK Germany 2
RTECS JM9230000
Packaging Group II
Hazard Class 3
HS Code 2929909090

 Synthetic Route

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

SILAZANE HMN
MFCD00008259
tsl8802
HEXAMETHYLISILAZNE
Hexamethyldisilazane
HMDS
1,1,1,3,3,3-hexamethyl-disilazane,lithium salt
hexamethylsilazane
EINECS 213-668-5
HMDZ
1,1,1,3,3,3-hexa-methyldisilazane
sz6079
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