thf

Modify Date: 2026-06-29 17:57:15

thf structure	Common Name	thf
	CAS Number	109-99-9	Molecular Weight	72.106
	Density	0.9±0.1 g/cm3	Boiling Point	66 ºC
	Molecular Formula	C₄H₈O	Melting Point	-108.4 ºC
	MSDS	Chinese USA	Flash Point	-21 ºC
	Symbol	GHS02, GHS07, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Tetrahydrofuran
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	66 ºC
Melting Point	-108.4 ºC
Molecular Formula	C₄H₈O
Molecular Weight	72.106
Flash Point	-21 ºC
Exact Mass	72.057518
PSA	9.23000
LogP	0.33
Vapour density	2.5 (vs air)
Vapour Pressure	152.4±0.1 mmHg at 25°C
Index of Refraction	1.417
InChIKey	WYURNTSHIVDZCO-UHFFFAOYSA-N
SMILES	C1CCOC1
Water Solubility	miscible
Freezing Point	-108℃

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

thf MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU5950000

CHEMICAL NAME :: Furan, tetrahydro-

CAS REGISTRY NUMBER :: 109-99-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 51

MOLECULAR FORMULA :: C4-H8-O

MOLECULAR WEIGHT :: 72.12

WISWESSER LINE NOTATION :: T5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 25000 ppm

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GAFCC* GAF Material Safety Data Sheet. (GAF Chemicals Corporation, 1361 Alps Road, Wayne, NJ 07470)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21000 ppm/3H

TOXIC EFFECTS :: Behavioral - sleep Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24000 mg/m3/2H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4550 mg/kg/17W-I

TOXIC EFFECTS :: Blood - change in clotting factors Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/4H/12W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5000 ppm/6H/91D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thymus weight Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/6H/18W-I

TOXIC EFFECTS :: Liver - other changes Musculoskeletal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4550 mg/kg/17W-I

TOXIC EFFECTS :: Blood - change in clotting factors Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 ppm/6H/91D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - adrenal cortex hypoplasia Endocrine - changes in thymus weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/m3/2H/60D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 5000 ppm/6H

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1800 ppm/6H

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 26(1),43,1982 *** REVIEWS *** ACGIH TLV-STEL 737 mg/m3 (250 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 590 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (590 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,252,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (590 mg/m3);STEL 250 ppm (735 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (590 mg/m3);STEL 250 ppm (738 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-FINLAND:TWA 100 ppm (290 mg/m3);STEL 150 ppm (440 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 400 mg/m3 JAN 1993 OEL-JAPAN:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993 OEL-SWEDEN:TWA 100 ppm (300 mg/m3);STEL 150 ppm (450 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (590 mg/m3);STEL 1000 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (590 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRAHYDROFURAN-air:10H TWA 200 ppm;STEL 250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71695 No. of Facilities: 4141 (estimated) No. of Industries: 72 No. of Occupations: 60 No. of Employees: 95003 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71695 No. of Facilities: 17866 (estimated) No. of Industries: 101 No. of Occupations: 83 No. of Employees: 356038 (estimated) No. of Female Employees: 47382 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H225-H302-H319-H335-H351
Supplemental HS	May form explosive peroxides.
Precautionary Statements	P210-P280-P301 + P312 + P330-P305 + P351 + P338-P370 + P378-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F:Flammable
Risk Phrases	R11;R19;R36/37
Safety Phrases	S26-S36-S33-S29-S16
RIDADR	UN 2924 3/PG 2
WGK Germany	1
RTECS	MD0916000
Packaging Group	II
Hazard Class	3
HS Code	2932110000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:110-63-4 1,4-Butanediol CAS#:110-65-6 2-Butine-1,4-diol CAS#:110-00-9 Furan CAS#:108-31-6 Maleic anhydride
CAS#:106-97-8 n-Butane CAS#:23055-10-9 DIMETHYL MALEATE CAS#:110-15-6 Succinic acid CAS#:96-48-0 gamma-Butyrolactone
CAS#:98-01-1 Furfural CAS#:124391-75-9 (3S)-oxolan-3-y...
DownStream 10
CAS#:1011-61-6 1,5-Pentanediol... CAS#:5371-52-8 2-Hydroxytetrah... CAS#:1198-37-4 4-Methylquinaldine CAS#:1076-28-4 Quinoline, 2-me...
CAS#:104293-35-8 4-(α-tetrahydro... CAS#:10157-78-5 2-ethylhexane-1... CAS#:109-73-9 n-butylamine CAS#:65007-00-3 2-pyridyl trifl...
CAS#:372-48-5 2-Fluoropyridine CAS#:111399-90-7 2-[(4-fluorobut...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2932110000
Summary	2932110000 tetrahydrofuran。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.0%。general tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream.

Eur. J. Pharm. Biopharm. 88(3) , 614-24, (2015)

A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to ...

Injectable Peptide Decorated Functional Nanofibrous Hollow Microspheres to Direct Stem Cell Differentiation and Tissue Regeneration.

Adv. Funct. Mater. 25(3) , 350-360, (2015)

Injectable microspheres are attractive stem cell carriers for minimally invasive procedures. For tissue regeneration, the microspheres need to present the critical cues to properly direct stem cell di...

Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery.

Nanotechnology 26(1) , 015602, (2015)

The possibility to direct pharmacological treatments targeting specific cell lines using polymer nanoparticles is one of the main novelties and perspectives in nanomedicine. However, sometimes, the ab...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

tetrahydro-furan

THF

oxolane

EINECS 203-786-5

MFCD00148879

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of Tetrahydrofuran?

A: Related upstream materials(CAS) of Tetrahydrofuran: 110-63-4;110-65-6;110-00-9;108-31-6;106-97-8;23055-10-9;110-15-6;96-48-0;98-01-1;124391-75-9.

Q: What English synonyms does Tetrahydrofuran have?

A: English synonyms of Tetrahydrofuran: tetrahydro-furan, THF, oxolane, EINECS 203-786-5, MFCD00148879.

Q: What is the LogP of Tetrahydrofuran?

A: LogP of Tetrahydrofuran is 0.33.

Q: What is the CAS number of Tetrahydrofuran?

A: CAS number of Tetrahydrofuran is 109-99-9.

Q: What is the English name of Tetrahydrofuran?

A: The English name of Tetrahydrofuran is Tetrahydrofuran.

Q: What is the boiling point of Tetrahydrofuran?

A: Boiling point of Tetrahydrofuran is 66 ºC.

Q: What is the polar surface area (PSA) of Tetrahydrofuran?

A: Polar surface area (PSA) of Tetrahydrofuran is 9.23000.

Q: What is the molecular weight of Tetrahydrofuran?

A: Molecular weight of Tetrahydrofuran is 72.106.

Q: What is the molecular formula of Tetrahydrofuran?

A: Molecular formula of Tetrahydrofuran is C4H8O.

Q: What are the downstream products of Tetrahydrofuran?

A: Related downstream products(CAS) of Tetrahydrofuran: 1011-61-6;5371-52-8;1198-37-4;1076-28-4;104293-35-8;10157-78-5;109-73-9;65007-00-3;372-48-5;111399-90-7.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: thf
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tetrahydrofuran
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

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thf | FAQ

thffactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.