2-Bromo-4-fluorobenzoic acid

Suppliers

Names

[ Name ]:
2-Bromo-4-fluorobenzoic acid

[Synonym ]:
4-Fluor-2-brom-benzoesaeure
Benzoic acid, 2-bromo-4-fluoro-
2-bromo-4-fluoro-benzoic acid
2-bromo-4-fluorobenzioc acid
4-fluoro-2-bromo-benzoic acid
RARECHEM AL BO 1996
3-Bromo-4-fluorobenzoic acid
2-Bromo-4-Fluorobenzoic
2-Brom-4-fluor-benzoesaeure
2-Bromo-4-fluorobenzoicacid
MFCD00055370
2-Bromo-4-fluorobenzoic acid
2-Bromofluorobenzoic Acid
Benzoic acid, 3-bromo-4-fluoro-

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
294.3±25.0 °C at 760 mmHg

[ Melting Point ]:
172-176 °C(lit.)

[ Molecular Formula ]:
C₇H₄BrFO₂

[ Molecular Weight ]:
219.008

[ Flash Point ]:
131.8±23.2 °C

[ Exact Mass ]:
217.937866

[ PSA ]:
37.30000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.583

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-Bromo-4-fluorobenzonitrile
2-Amino-4-fluorobenzoic acid
4-Fluorobenzoic acid
Methyl 2-bromo-4-fluorobenzoate
2-Bromo-4-fluorobenzaldehyde
2-BROMO-4-FLUORO-N-METHYLBENZAMIDE
2-Bromo-4-fluoro-5-nitrobenzoic Acid
(2-Bromo-4-fluorophenyl)methanamine hydrochloride
(2-Bromo-4-fluorophenyl)methanol
tert-butyl 4-bromo-1H-indazole-5-carboxylate

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Bioorg. Med. Chem. 19(7) , 2190-8, (2011)

Aim of this study was to label the potent dual P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor elacridar (1) with (18)F to provide a positron emission tomography (PET) radio...

Regioselective copper-catalyzed amination of bromobenzoic acids using aliphatic and aromatic amines.

J. Org. Chem. 71(8) , 3270-3, (2006)

A chemo- and regioselective copper-catalyzed cross-coupling procedure for amination of 2-bromobenzoic acids is described. The method eliminates the need for acid protection and produces N-aryl and N-a...

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library.

Org. Biomol. Chem. 9(7) , 2233-9, (2011)

A Heck cyclisation approach is described for the rapid synthesis of a library of natural product-like small molecules, based on the phenanthridine core. The synthesis of a range of substituted benzyla...