L-655238

Names

[ CAS No. ]:
101910-24-1

[ Name ]:
L-655238

[Synonym ]:
rev-5901
rg 5901
Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
1-[3-(2-Quinolinylmethoxy)phenyl]-1-hexanol
pf 5901
1-[3-(Quinolin-2-ylmethoxy)phenyl]hexan-1-ol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
497.7±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₅NO₂

[ Molecular Weight ]:
335.439

[ Flash Point ]:
254.8±25.9 °C

[ Exact Mass ]:
335.188538

[ PSA ]:
42.35000

[ LogP ]:
4.94

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.606

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(Chloromethyl)quinoline
Benzenemethanol, 3-hydroxy-α-pentyl
3-ACETYLPHENOL
Pentyl magnesium bromide
3-Hydroxybenzaldehyde
2-(Chloromethyl)quinoline hydrochloride
Quinaldine
Quinoline, 2-methyl-,1-oxide

DownStream

Articles

Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.

Inflammation 26(2) , 61-71, (2002)

The initial phase of zymosan-induced peritonitis involves an increase of vascular permeability (peak at 30 min) that is correlated with high levels of vasoactive eicosanoids, namely, prostaglandins (P...

Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Eur. J. Pharmacol. 459(1) , 27-39, (2003)

Conventional intracellular microelectrodes, neuronal tracer injection techniques and immunohistochemistry were used to study the actions of cysteinyl leukotrienes (CysLTs) on electrical and synaptic b...

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

J. Cell Physiol. 192(2) , 188-99, (2002)

The effects of LY-171883, an orally active leukotriene antagonist, on membrane currents were examined in pituitary GH(3) and in neuroblastoma IMR-32 cells. In GH(3) cells, LY-171883 (1-300 microM) rev...