L-655238
L-655238 structure
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Common Name | L-655238 | ||
|---|---|---|---|---|
| CAS Number | 101910-24-1 | Molecular Weight | 335.439 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 497.7±35.0 °C at 760 mmHg | |
| Molecular Formula | C22H25NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 254.8±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Inflammation 26(2) , 61-71, (2002) The initial phase of zymosan-induced peritonitis involves an increase of vascular permeability (peak at 30 min) that is correlated with high levels of vasoactive eicosanoids, namely, prostaglandins (PGI2 and PGE2) of cyclooxygenase-1 origin (as estimated by R... |
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Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.
Eur. J. Pharmacol. 459(1) , 27-39, (2003) Conventional intracellular microelectrodes, neuronal tracer injection techniques and immunohistochemistry were used to study the actions of cysteinyl leukotrienes (CysLTs) on electrical and synaptic behavior of enteric neurons in guinea-pig stomach and small ... |
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Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.
J. Cell Physiol. 192(2) , 188-99, (2002) The effects of LY-171883, an orally active leukotriene antagonist, on membrane currents were examined in pituitary GH(3) and in neuroblastoma IMR-32 cells. In GH(3) cells, LY-171883 (1-300 microM) reversibly increased the amplitude of Ca(2+)-activated K(+) cu... |
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Control of chondrocyte regulatory volume decrease (RVD) by [Ca2+]i and cell shape.
Osteoarthr. Cartil. 16(3) , 312-22, (2008) Optimal matrix metabolism by articular chondrocytes is controlled by the 'set-point' volume which is determined mainly by membrane transporters. The signal transduction pathway(s) for the key membrane transporter which responds to cell swelling ('osmolyte cha... |
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A new class of leukotriene biosynthesis inhibitor: the development of MK-0591.
J. Lipid Mediat. 6(1-3) , 239-44, (1993) The evolution of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy+ ++)indol-2-yl]- 2,2-dimethylpropanoic acid), 12, a potent, orally active leukotriene biosynthesis inhibitor is described. MK-0591 is currently undergoing clinical evaluat... |
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Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits.
Br. J. Pharmacol. 107(4) , 1108-15, (1992) 1. Aerosol administration of platelet activating factor (PAF) (80 micrograms ml-1 for 60 min) to neonatally immunized rabbits caused bronchoconstriction which was far in excess of that produced by a comparable aerosol of bovine serum albumin (BSA), the carrie... |
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Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone.
J. Endocrinol. 149(2) , 269-75, (1996) We have shown that superoxide anion (O2-) production by the osteoclast can be used as an index of the osteoclast activity since the agents that inhibit and stimulate the osteoclast also diminish and stimulate O2- production respectively. Therefore, we have in... |
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Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Biochem. Biophys. Res. Commun. 266(2) , 392-9, (1999) Epidemiologic and animal studies have linked pancreatic cancer growth with fat intake, especially unsaturated fats. Arachidonic acid release from membrane phospholipids is essential for tumor cell proliferation. Lipoxygenases (LOX) constitute one pathway for ... |
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Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 295(1) , G1-G6, (2008) In a rabbit model of chronic intestinal inflammation, we previously demonstrated inhibition of neutral Na-amino acid cotransport. The mechanism of the inhibition was secondary to a decrease in the affinity for amino acid rather than the number of cotransporte... |
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The role of a swelling-activated taurine transport pathway in the regulation of articular chondrocyte volume.
Pflugers Arch. 442(5) , 771-81, (2001) Swelling articular chondrocytes by reducing osmolarity stimulates a taurine transport pathway, which is implicated in regulatory volume decrease (RVD) in various cell types. The present study investigated factors controlling the activity of this pathway in ch... |